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首页> 外文期刊>Acta anaesthesiologica Taiwanica : >Anesthesia for oncogenic osteomalacia-A rare paraneoplastic syndrome
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Anesthesia for oncogenic osteomalacia-A rare paraneoplastic syndrome

机译：致癌性骨软化症的麻醉-一种罕见的副肿瘤综合征

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Two patients with a diagnosis of oncogenic osteomalacia are described. This rare disease, characterized by secretion of fibroblast growth factor-23 by the tumor cells, causes myopathy, extreme debilitation and severe osteopathy because of severe hypophosphatemia. Both patients presented with severe bone pain, pathological fractures and proximal muscle weakness. Multiple diagnostic tools had to be utilized to settle the diagnosis of this rare disease. Although supplemental therapy for hypophosphatemia is usually started preoperatively, surgical excision of the causative tumor is the only definite treatment. Surgery is almost always curative; however, there is a lack of discourse in the literature regarding the anesthetic implications for the disease. The complete pathophysiology of the disease, clinical picture, its diagnostic intricacies as well as the salient points in its anesthetic management are discussed in this report.
机译：描述了两名诊断为致癌性骨软化症的患者。这种罕见的疾病以肿瘤细胞分泌成纤维细胞生长因子-23为特征，由于严重的低磷血症，会引起肌病，极度虚弱和严重的骨病。两名患者均出现严重的骨痛，病理性骨折和近端肌无力。必须使用多种诊断工具来解决这种罕见疾病的诊断。尽管低磷血症的补充治疗通常在术前开始，但是手术切除引起原因的肿瘤是唯一的明确治疗方法。手术几乎总是可以治愈的。然而，在文献中缺乏关于麻醉对疾病的影响的论述。本报告讨论了该疾病的完整病理生理学，临床表现，诊断的复杂性以及麻醉处理的要点。

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