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首页> 外文期刊>American Journal of Biochemistry >Association of Interleukin 23 and Anti-ficolin -2 Antibodies with Lupus Nephritis
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Association of Interleukin 23 and Anti-ficolin -2 Antibodies with Lupus Nephritis

机译：白细胞介素23和抗纤维胶凝蛋白-2抗体与狼疮性肾炎的关联

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Objective : To analyzed the serum concentration of Anti-ficolin 2 antibodies and Interleukin 23 in SLE patients and to evaluate the association between their levels with disease activity and also degree of lupus nephritis. Patients and methods: The present study included 90 subjects, 70 SLE patients (40 patients with lupus nephritis (LN), 30 SLE patients without LN), and 20 age and sex matched healthy control (HC). An enzyme-linked immunosorbent assay (ELISA) was used to analyze the serum concentration of Anti-ficolin 2 antibodies and IL 23. The correlations between the levels of Anti-ficolin 2 antibodies, IL-23, and disease activity, clinical parameters in SLE patients were analyzed. Results: Levels of IL-23 and anti ficolin-2 auto antibodies were significantly higher in patients with SLE compared with healthy controls, and in patients with SLE and renal involvement (LN patients) compared with SLE alone (Non LN patients). Patients with proliferative LN had significantly more IL23 and anti-ficolin-2 antibodies than those with non-proliferative LN. Anti-ficolin-2 antibodies were associated with the SLEDAI score. Conclusion: Our findings suggest that IL-23 and anti-ficolin-2 may be useful biomarkers for the diagnosis of SLE with renal manifestation.
机译：目的：分析SLE患者的抗Ficolin 2抗体和白细胞介素23的血清浓度，并评估其水平与疾病活动性以及狼疮性肾炎程度之间的关系。 患者和方法：本研究包括90名受试者，70名SLE患者（40名患有狼疮性肾炎（LN）的患者，30名无LN的SLE患者）以及20个年龄和性别相匹配的健康对照（HC ）。酶联免疫吸附试验（ELISA）用于分析抗Ficolin 2抗体和IL 23的血清浓度。抗Ficolin 2抗体的水平，IL-23与疾病活性，SLE中的临床参数之间的相关性对患者进行了分析。 结果：与健康对照组相比，SLE患者的IL-23和抗Ficolin-2自身抗体水平显着更高，SLE和肾脏受累的患者（LN患者）与单独的SLE相比（非LN患者） 。 LN增生患者比非LN增生患者具有更多的IL23和抗Ficolin-2抗体。抗ficolin-2抗体与SLEDAI评分相关。 结论：我们的研究结果提示IL-23和抗纤维胶凝蛋白2可能是诊断具有肾脏表现的SLE的有用生物标志物。

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