Case 1: A 15-month-old boy presented with a 4-day history of pruritic erythematous edematous plaques, some with dusky purple center, on the face, the trunk, arms and legs. The duration of individual urticarial lesions was less than 24 h. He received intramuscular penicillin G benzathine for pharyngitis one day prior to the onset of the cutaneous eruption. The initial hypotheses were acute urticaria, urticarial vasculitis and acute hemorrhagic edema of infancy. Complete blood count (CBC), erythrocyte sedimentation rate (ERS) and urinalysis were normal and C-reactive protein was 14,45 mg/ml (normal < 5,0 mg/ml). The histopathological exam showed epidermis preserved, dermis and superior hypodermis with perivascular and interstitial mixed infiltrate with eosinophils and neutrophils. These findings were suggestive of urticaria (Fig. 1). The patient was treated with oral corticosteroid and the lesions faded in a few days.
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