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首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration
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A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration

机译：一例胆碱能性荨麻疹伴局部汗湿表现为汗腺嗜酸性粒细胞浸润

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The physical findings showed punctate wheals and/or a flare response on her forearm and trunk. Neurological examinations and blood test for immunological disorders was negative. Serum immunoglobulin E level was within the normal range. The thermoregulatory sweat test showed diminished black dots on the left leg (Fig. 1a and b). Thermographic testing showed a decrease in skin temperature 30 min after exercise in all areas except the left leg (Fig. 1c). Skin biopsies taken from both the hypohidrotic and wheals areas were examined. In the wheals area, the epidermis was unchanged and significant edema was not observed in the upper dermis. Eosinophils were infiltrated around sweat glands and the blood vessels though vasculitis was denied (Fig. 2a). There was no evidence of atrophy of the sweat glands or occlusion of the duct spaces (Fig. 2b). Eosinophils were infiltration around the eccrine glands as well (Fig. 2b). In the hypohidrotic areas, eosinophils were not infiltrated around of the glands (Fig. 2c). There was no evidence of atrophy of the sweat glands or occlusion of the duct spaces (Fig. 2c). The cholinergic urticaria with hypohidrosis was treated with three sessions of methylprednisolone 1000 mg intravenously for 3 days, but it was not responsive. Cyclosporine therapy with the dose of 3 mg/kg/day then began and resulted in no recurrence of urticarial lesion with burning pain in 2 months.
机译：体格检查发现前臂和躯干出现点状的鞭子和/或耀斑反应。免疫性疾病的神经系统检查和血液检查均为阴性。血清免疫球蛋白E水平在正常范围内。体温调节汗液测试显示左腿黑点减少（图1a和b）​​。热成像测试表明，运动后30分钟，除左腿外，所有部位的皮肤温度均下降（图1c）。检查了从多汗和下睑区域的皮肤活检。在风团区域，表皮未变，在上层真皮未观察到明显的水肿。嗜酸性粒细胞浸润在汗腺和血管周围，尽管血管炎被否认（图2a）。没有证据显示汗腺萎缩或导管间隙闭塞（图2b）。嗜酸性粒细胞也渗入内分泌腺周围（图2b）。在汗湿少的区域，嗜酸性粒细胞未浸入腺体周围（图2c）。没有证据表明汗腺萎缩或导管间隙闭塞（图2c）。患有多汗症的胆碱能性荨麻疹用3次1000 mg甲基强的松龙静脉内治疗3天，但无反应。然后开始以3 mg / kg / day的剂量进行环孢霉素治疗，并在2个月内没有复发性荨麻疹病变并伴有灼痛。

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