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首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Cysteinyl leukotriene metabolism of human eosinophils in allergic disease
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Cysteinyl leukotriene metabolism of human eosinophils in allergic disease

机译：人类嗜酸性粒细胞在过敏性疾病中的半胱氨酸白三烯代谢

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Eosinophils are multifaceted immune cells with diverse functions that enhance allergic inflammation. Cysteinyl leukotrienes (cys-LTs), mainly synthesized in eosinophils, are a class of inflammatory lipid mediators produced via multiple enzymatic reactions from arachidonic acid. Multiple clinical studies have reported dysregulated fatty acid metabolism in severe asthma and aspirin-exacerbated respiratory diseases. Therefore, understanding the mechanism responsible for this metabolic abnormality has attracted a lot of attention. In eosinophils, various stimuli (including cytokines, chemokines, and pathogen-derived factors) prime and/or induce leukotriene generation and secretion. Cell–cell interactions with component cells (endothelial cells, epithelial cells, fibroblasts) also enhance this machinery to augment allergic responses. Nasal polyp-derived eosinophils from patients with eosinophilic rhinosinusitis present a characteristic fatty acid metabolism with selectively higher production of leukotriene D4. Interestingly, type 2 cytokines and microbiome components might be responsible for this metabolic change with altered enzyme expression. Here, we review the regulation of fatty acid metabolism, especially cys-LT metabolism, in human eosinophils toward allergic inflammatory status.
机译：嗜酸性粒细胞是具有多种功能的多方面免疫细胞，可增强过敏性炎症。半胱氨酸白三烯（cys-LTs）主要在嗜酸性粒细胞中合成，是一类通过花生四烯酸的多种酶促反应产生的炎症脂质介体。多项临床研究报道了严重哮喘和阿司匹林加重的呼吸系统疾病中脂肪酸代谢失调。因此，了解引起这种代谢异常的机理引起了很多关注。在嗜酸性粒细胞中，各种刺激（包括细胞因子，趋化因子和病原体衍生因子）引发和/或诱导白三烯的生成和分泌。细胞与组成细胞（内皮细胞，上皮细胞，成纤维细胞）的相互作用也增强了这种机制，以增强过敏反应。来自嗜酸性鼻鼻窦炎患者的鼻息肉来源的嗜酸性粒细胞表现出特征性的脂肪酸代谢，并选择性地产生了较高的白三烯D4。有趣的是，2型细胞因子和微生物组成分可能是这种代谢变化和酶表达改变的原因。在这里，我们回顾了人类嗜酸性粒细胞中脂肪酸代谢特别是cys-LT代谢对过敏性炎症状态的调节。

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