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首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Usefulness of antigen-specific IgE probability curves derived from the 3gAllergy assay in diagnosing egg, cow's milk, and wheat allergies
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Usefulness of antigen-specific IgE probability curves derived from the 3gAllergy assay in diagnosing egg, cow's milk, and wheat allergies

机译：从3gAllergy分析得出的抗原特异性IgE概率曲线在诊断鸡蛋，牛奶和小麦过敏中的有用性

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Background Specific IgE (sIgE) antibody detection using the Siemens IMMULITE ? 3gAllergy? (3gAllergy) assay have not been sufficiently examined for the diagnosis of food allergy. The aim of this study was to evaluate the utility of measuring sIgE levels using the 3gAllergy assay to diagnose allergic reactions to egg, milk, and wheat. Methods This retrospective study was conducted on patients with diagnosed or suspected allergies to egg, milk and wheat. Patients were divided into two groups according to their clinical reactivity to these allergens based on oral food challenge outcomes and/or convincing histories of immediate reaction to causative food(s). The sIgE levels were measured using 3gAllergy and ImmunoCAP. Predicted probability curves were estimated using logistic regression analysis. Results We analyzed 1561 patients, ages 0–19?y (egg?=?436, milk?=?499, wheat?=?626). The sIgE levels determined using 3gAllergy correlated with those of ImmunoCAP, classifying 355 patients as symptomatic: egg?=?149, milk?=?123, wheat?=?83. 3gAllergy sIgE levels were significantly higher in symptomatic than in asymptomatic patients ( P ??0.0001). Predictive probability for positive food allergy was significantly increased and correlated with increased sIgE levels. The cut-offs for allergic reaction with 95% predictive probability as determined by the 3gAllergy probability curves were different from those of ImmunoCAP. Conclusions Measurements of sIgE against egg, milk, and wheat as determined by 3gAllergy may be used as a tool to facilitate the diagnosis of food allergy in subjects with suspected food allergies. However, these probability curves should not be applied interchangeably between different assays.
机译：使用SiemensIMMULITE®检测背景特异性IgE（sIgE）抗体3g过敏？ （3gAllergy）测定法尚未对食品过敏的诊断进行充分检查。这项研究的目的是评估使用3gAllergy测定法测量sIgE水平来诊断对鸡蛋，牛奶和小麦的过敏反应的实用性。方法这项回顾性研究是针对被诊断或怀疑对鸡蛋，牛奶和小麦过敏的患者进行的。根据口服食物挑战的结果和/或令人信服的对病原性食物的反应史，根据患者对这些过敏原的临床反应将其分为两组。使用3gAllergy和ImmunoCAP测量sIgE水平。预测的概率曲线使用逻辑回归分析进行估计。结果我们分析了1561名年龄在0-19岁之间的患者（例如，鸡蛋== 436，牛奶== 499，小麦== 626）。使用3gAllergy确定的sIgE水平与ImmunoCAP的相关性，将355例有症状的患者分类为：鸡蛋== 149，牛奶== 123，小麦== 83。有症状的3g过敏sIgE水平明显高于无症状的患者（P 0.0001）。积极食物过敏的预测概率显着增加，并与sIgE水平升高相关。由3gAllergy概率曲线确定的具有95％预测概率的过敏反应的临界值不同于ImmunoCAP。结论通过3gAllergy测定的针对鸡蛋，牛奶和小麦的sIgE的测量可用于辅助诊断可疑食物过敏患者的食物过敏。但是，这些概率曲线不应在不同的测定方法之间互换使用。

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