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首页> 外文期刊>American Journal of Cancer Prevention >Type of Treatment Can Effect on Transformation of Chronic Lymphocytic Leukaemia to Diffuse Large B-cell Lymphoma: A Rare Case with Review of Literature
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Type of Treatment Can Effect on Transformation of Chronic Lymphocytic Leukaemia to Diffuse Large B-cell Lymphoma: A Rare Case with Review of Literature

机译：治疗类型可影响将慢性淋巴细胞白血病转化为弥漫性大B细胞淋巴瘤的罕见病例：文献复习

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摘要

Richter transformation is defined as a diffuse large cell lymphoma, occurring by transformation of chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL) is the most common type of richter syndrome. Herein, we describe report of a 51 year-old man in western Iran that referred to Hematology Clinic with complaint of three months of weight loss and sweating with generalized abdominal lymphadenopathy and the Bulky cervical lymph node. Pathology’s specimens for him demonstrated CLL in the patient (Rai system stage 4) and during seven years ago, he was treated with fludarabine and cyclophosphamide regiment for 6 courses. Cervical biopsy pathology reported a new diagnosis of diffuse large B-Cell lymphoma and also immunohistochemistry (IHC) analysis showed CD3, CD20, CD45 were positive and Bcl-2 was negative and so he was treated with new regiment of R-CHOP for 6 courses. One month after last course of chemotherapy, Cerebrospinal fluid cytology was positive with lymphomatous involvement, and also brain CT SCAN showed parenchymal involvement and therapy with high dose Methotrexate began for him. The result is that specialists should be careful that probably fludarabin therapy alone or combination it with other drug especially cyclophosphamide can effect on transformation CLL to DLBCL.
机译：Richter转化定义为通过慢性淋巴细胞性白血病（CLL）转化而发生的弥散性大细胞淋巴瘤，而弥散性大B细胞淋巴瘤（DLBCL）是Richter综合征最常见的类型。本文中，我们描述了伊朗西部一位51岁男性的报告，该患者提到血液学诊所，抱怨体重减轻和出汗三个月，并伴有全身性腹部淋巴结肿大和颈部颈淋巴结肿大。病理标本对他显示出患者的CLL（Rai系统第4阶段），在七年前，他接受了氟达拉滨和环磷酰胺治疗6个疗程。宫颈活检病理报告为弥漫性大B细胞淋巴瘤的新诊断，免疫组织化学（IHC）分析显示CD3，CD20，CD45阳性，Bcl-2阴性，因此他接受了新的R-CHOP方案治疗6个疗程。化疗最后一个疗程一个月后，脑脊髓液细胞学检查阳性并伴有淋巴瘤，并且脑部CT SCAN也显示出实质性受累，并开始使用高剂量甲氨蝶呤治疗。结果是，专家们应谨慎行事，单独使用氟达拉宾疗法或与其他药物（尤其是环磷酰胺）联合使用，可能会影响CLL向DLBCL的转化。

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