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首页> 外文期刊>American Journal of Drug Discovery and Development >Effect of Capsaicin on the Climbing Ability in Drosophila Model of Parkinson?s Disease
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Effect of Capsaicin on the Climbing Ability in Drosophila Model of Parkinson?s Disease

机译：辣椒素对帕金森病果蝇模型攀爬能力的影响

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摘要

Parkinson’s Disease (PD) is characterized by the progressive loss of dopaminergic neurons. Drosophila mutants and transgenes have provided a platform to understand the mechanistic insight associated with the degenerative disease. In the present study, the effect of capsaicin was studied on the climbing ability of the PD model Drosophila expressing normal human alpha synuclein (h-αS) in the neurons. These flies exhibit locomotor dysfunction as the age progresses. Capsaicin at final concentration of 0.1, 0.5, 0.75 and 1.0 μL mL-1 was supplemented with the diet and the flies were allowed to feed for the 21 days. Capsaicin showed a dose dependent significant (p<0.05) delay in the loss of climbing ability of PD model flies as compared to the untreated PD flies. The results suggest that the capsaicin is potent in delaying the climbing disability of PD model flies and also supports the utility of this model in studying PD symptoms.
机译：帕金森氏病（PD）的特征在于多巴胺能神经元的进行性丧失。果蝇突变体和转基因提供了一个平台，以了解与退行性疾病有关的机制的见解。在本研究中，研究了辣椒素对PD模型果蝇在神经元中表达正常人α突触核蛋白（h-αS）的爬升能力的影响。随着年龄的增长，这些苍蝇表现出运动功能障碍。向日粮中添加最终浓度为0.1、0.5、0.75和1.0μLmL-1的辣椒素，并让果蝇采食21天。与未处理的PD果蝇相比，辣椒素显示PD模型果蝇的爬升能力丧失的剂量依赖性显着（p ＜0.05）延迟。结果表明，辣椒素有效延缓了PD模型果蝇的爬升障碍，也支持了该模型在研究PD症状中的实用性。

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