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首页> 外文期刊>American Journal of Microbiology >Exogenous Pyocyanin Alters Pseudomonas aeruginosa Susceptibility to Ciprofloxacin | Science Publications
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Exogenous Pyocyanin Alters Pseudomonas aeruginosa Susceptibility to Ciprofloxacin | Science Publications

机译：外源性花青素改变铜绿假单胞菌对环丙沙星的敏感性科学出版物

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> This in vitro cell-based study identified the contributing role of pyocyanin in the resistance of Pseudomonas aeruginosa to ciprofloxacin. Problem statement: P. aeruginosa is the major pathogen in the Cystic Fibrosis (CF) lung with pyocyanin being a critical component of its virulence. Prevalence is high and, once acquired, chronic infection is difficult to eliminate. Ciprofloxacin remains a crucial oral agent effective against P. aeruginosa, but resistance is increasingly reported. Approach: Here we examined the extent to which exogenously added pyocyanin affected P. aeruginosa susceptibility to ciprofloxacin and the contribution of altered efflux activity and biofilm production with the aim of ultimately increasing sensitivity. Results: Metabolic conversion of resazurin to resorufin was used as an index of bacterial cell growth while fluorescent measurement of acriflavine efflux and crystal violet staining was used as markers of efflux activity and biofilm production, respectively. Pyocyanin (100
机译： >这项基于体外细胞的研究确定了绿脓素在铜绿假单胞菌对环丙沙星耐药性中的作用。 问题陈述： P。铜绿假单胞菌是囊性纤维化（CF）肺中的主要病原体，其花青素是其致病力的重要组成部分。患病率很高，一旦获得，就很难消除慢性感染。环丙沙星仍然是有效抗P的关键口服药物。铜绿假单胞菌，但耐药性越来越多。 方法：在这里，我们检查了外源添加的洋蓝蛋白对 P的影响程度。铜绿假单胞菌对环丙沙星的敏感性以及外排活性和生物膜产生改变的作用，目的是最终提高敏感性。 结果：刃天青的代谢转化为间苯二酚被用作​​细菌细胞生长的指标，而fla啶黄酮外排的荧光测量和结晶紫染色被用作外排活性和生物膜产生的标志。绿脓素（100

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