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首页> 外文期刊>Aging cell. >Exercise‐stimulated interleukin‐15 is controlled by AMPK and regulates skin metabolism and aging
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Exercise‐stimulated interleukin‐15 is controlled by AMPK and regulates skin metabolism and aging

机译：运动刺激的白介素15受AMPK控制并调节皮肤新陈代谢和衰老

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SummaryAging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefits, there is no evidence that it affects skin tissue or that endocrine muscle-to-skin signaling occurs. We demonstrate that endurance exercise attenuates age-associated changes to skin in humans and mice and identify exercise-induced IL-15 as a novel regulator of mitochondrial function in aging skin. We show that exercise controls IL-15 expression in part through skeletal muscle AMP-activated protein kinase (AMPK), a central regulator of metabolism, and that the elimination of muscle AMPK causes a deterioration of skin structure. Finally, we establish that daily IL-15 therapy mimics some of the anti-aging effects of exercise on muscle and skin in mice. Thus, we elucidate a mechanism by which exercise confers health benefits to skin and suggest that low-dose IL-15 therapy may prove to be a beneficial strategy to attenuate skin aging.
机译：总结衰老通常与皮肤的结构恶化相关，损害其屏障功能，愈合和对疾病的敏感性。几条证据表明，这些变化很大程度上是由组织线粒体代谢受损所驱动。尽管锻炼具有许多健康益处，但没有证据表明锻炼会影响皮肤组织或发生内分泌肌肉对皮肤的信号传导。我们证明了耐力运动减弱了人类和小鼠皮肤年龄相关的变化，并确定了运动诱导的IL-15作为老化皮肤线粒体功能的新型调节剂。我们表明运动控制通过骨骼肌AMP激活的蛋白激酶（AMPK），代谢的中央调节器，部分控制IL-15的表达，并且消除肌肉AMPK会导致皮肤结构的恶化。最后，我们确定每日IL-15治疗可模拟运动对小鼠肌肉和皮肤的某些抗衰老作用。因此，我们阐明了运动赋予皮肤健康益处的机制，并建议低剂量IL-15治疗可能被证明是减轻皮肤衰老的有益策略。

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