...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advances in Nephrology >Calcium Carbonate versus Sevelamer Hydrochloride as Phosphate Binders after Long-Term Disease Progression in 5/6 Nephrectomized Rats
【24h】

Calcium Carbonate versus Sevelamer Hydrochloride as Phosphate Binders after Long-Term Disease Progression in 5/6 Nephrectomized Rats

机译：5/6肾切除大鼠长期疾病进展后，碳酸钙与盐酸司维拉姆作为磷酸盐结合剂

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our aim was to compare the effects of calcium carbonate and sevelamer-HCl treatments on calcium-phosphate metabolism and renal function in 5/6 nephrectomized (NX) rats so that long-term disease progression preceded the treatment. After 15-week progression, calcium carbonate (3.0%), sevelamer-HCl (3.0%), or control diets (0.3% calcium) were given for 9 weeks. Subtotal nephrectomy reduced creatinine clearance (−40%), plasma calcidiol (−25%), and calcitriol (−70%) and increased phosphate (+37%), parathyroid hormone (PTH) (11-fold), and fibroblast growth factor-23 (FGF-23) (4-fold). In NX rats, calcium carbonate diet increased plasma (+20%) and urinary calcium (6-fold), reduced plasma phosphate (−50%) and calcidiol (−30%), decreased creatinine clearance (−35%) and FGF 23 (−85%), and suppressed PTH without influencing blood pH. In NX rats, sevelamer-HCl increased urinary calcium (4-fold) and decreased creatinine clearance (−45%), PTH (−75%), blood pH (by 0.20 units), plasma calcidiol (−40%), and calcitriol (−65%). Plasma phosphate and FGF-23 were unchanged. In conclusion, when initiated after long-term progression of experimental renal insufficiency, calcium carbonate diet reduced plasma phosphate and FGF-23 while sevelamer-HCl did not. The former induced hypercalcemia, the latter induced acidosis, while both treatments reduced vitamin D metabolites and deteriorated renal function. Thus, delayed initiation influences the effects of these phosphate binders in remnant kidney rats.
机译：我们的目的是比较5/6肾切除（NX）大鼠中碳酸钙和司维拉姆-盐酸治疗对磷酸钙代谢和肾功能的影响，从而使长期疾病进展先于治疗。进展15周后，给予碳酸钙（3.0％），司维拉姆盐酸盐（3.0％）或对照饮食（0.3％钙），持续9周。全肾切除术降低了肌酐清除率（−40％），血浆骨化二醇（−25％）和骨化三醇（−70％）并增加了磷酸盐（+ 37％），甲状旁腺激素（PTH）（11倍）和成纤维细胞生长因子-23（FGF-23）（4倍）。在NX大鼠中，碳酸钙饮食增加血浆（+ 20％）和尿钙（6倍），减少血浆磷酸盐（−50％）和骨化二醇（−30％），减少肌酐清除率（−35％）和FGF 23 （-85％），并且在不影响血液pH的情况下抑制了PTH。在NX大鼠中，盐酸司维拉姆使尿钙增加（4倍），而肌酐清除率（−45％），PTH（−75％），血液pH（降低0.20单位），血浆降钙糖（−40％）和骨化三醇降低（-65％）。血浆磷酸盐和FGF-23未改变。总而言之，当在实验性肾功能不全的长期进展后开始时，碳酸钙饮食会降低血浆磷酸盐和FGF-23，而司维拉姆盐酸盐则不能。前者引起高钙血症，后者引起酸中毒，而两种治疗均降低维生素D代谢产物并恶化肾功能。因此，延迟的启动会影响这些磷酸盐结合剂在残余肾脏大鼠中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号