• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Aging cell. >A critical role for the glial-derived neuromodulator d-serine in the age-related deficits of cellular mechanisms of learning and memory
【24h】

A critical role for the glial-derived neuromodulator d-serine in the age-related deficits of cellular mechanisms of learning and memory

机译：胶质细胞源性神经调节剂d-丝氨酸在与年龄相关的学习和记忆细胞机制缺陷中的关键作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Age-associated deficits in learning and memory are closely correlated with impairments of synaptic plasticity. Analysis of N -methyl-D-aspartate receptor (NMDAr)-dependent long-term potentiation (LTP) in CA1 hippocampal slices indicates that the glial-derived neuromodulator d -serine is required for the induction of synaptic plasticity. During aging, the content of d -serine and the expression of its synthesizing enzyme serine racemase are significantly decreased in the hippocampus. Impaired LTP and NMDAr-mediated synaptic potentials in old rats are rescued by exogenous d -serine. These results highlight the critical role of glial cells and presumably astrocytes, through the availability of d -serine, in the deficits of synaptic mechanisms of learning and memory that occur in the course of aging.
机译：与年龄相关的学习和记忆缺陷与突触可塑性的损害密切相关。对CA1海马切片中N-甲基-D-天冬氨酸受体（NMDAr）依赖性长期增强（LTP）的分析表明，胶质细胞衍生的神经调节剂d-丝氨酸诱导突触可塑性。在衰老过程中，海马中d-丝氨酸的含量及其合成酶丝氨酸消旋酶的表达显着降低。 LTP和NMDAr介导的突触电位受损可通过外源性d-丝氨酸挽救。这些结果通过衰老过程中发生的学习和记忆的突触机制的缺陷，通过d-丝氨酸的可用性突出了神经胶质细胞和推测的星形胶质细胞的关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号