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首页> 外文期刊>Aging cell. >The Human Ageing Genomic Resources: online databases and tools for biogerontologists
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The Human Ageing Genomic Resources: online databases and tools for biogerontologists

机译：人类衰老基因组资源：生物老年学家的在线数据库和工具

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Aging is a complex, challenging phenomenon that requires multiple, interdisciplinary approaches to unravel its puzzles. To assist basic research on aging, we developed the Human Ageing Genomic Resources (HAGR). This work provides an overview of the databases and tools in HAGR and describes how the gerontology research community can employ them. Several recent changes and improvements to HAGR are also presented. The two centrepieces in HAGR are GenAge and AnAge. GenAge is a gene database featuring genes associated with aging and longevity in model organisms, a curated database of genes potentially associated with human aging, and a list of genes tested for their association with human longevity. A myriad of biological data and information is included for hundreds of genes, making GenAge a reference for research that reflects our current understanding of the genetic basis of aging. GenAge can also serve as a platform for the systems biology of aging, and tools for the visualization of protein–protein interactions are also included. AnAge is a database of aging in animals, featuring over 4000 species, primarily assembled as a resource for comparative and evolutionary studies of aging. Longevity records, developmental and reproductive traits, taxonomic information, basic metabolic characteristics, and key observations related to aging are included in AnAge. Software is also available to aid researchers in the form of Perl modules to automate numerous tasks and as an SPSS script to analyse demographic mortality data. The HAGR are available online at http://genomics.senescence.info .
机译：老龄化是一个复杂的，具有挑战性的现象，需要多种跨学科的方法来解开其难题。为了协助进行衰老的基础研究，我们开发了人类衰老基因组资源（HAGR）。这项工作概述了HAGR中的数据库和工具，并描述了老年医学研究界如何使用它们。还介绍了HAGR的一些最新更改和改进。 HAGR的两个核心要素是GenAge和AnAge。 GenAge是一个基因数据库，其特征在于与模型生物中的衰老和长寿相关的基因，经过整理的可能与人类衰老相关的基因数据库以及经过测试的与人类长寿相关的基因列表。其中包含数百种基因的大量生物学数据和信息，使GenAge成为反映我们目前对衰老的遗传基础的理解的研究参考。 GenAge还可以用作老化系统生物学的平台，并且还包括可视化蛋白质相互作用的工具。 AnAge是动物衰老的数据库，拥有4000多种物种，主要作为对衰老进行比较和进化研究的资源而建立。长寿记录，发育和生殖性状，分类学信息，基本代谢特征以及与衰老有关的主要观察结果均包含在AnAge中。还可以通过Perl模块的形式来帮助研究人员使用该软件来自动化许多任务，并可以使用SPSS脚本来分析人口统计数据。 HAGR可从http://genomics.senescence.info在线获得。

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