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首页> 外文期刊>Aging cell. >Decreasing initial telomere length in humans intergenerationally understates age‐associated telomere shortening
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Decreasing initial telomere length in humans intergenerationally understates age‐associated telomere shortening

机译：代际减少人类的初始端粒长度低估了与年龄相关的端粒缩短

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SummaryTelomere length shortens with aging, and short telomeres have been linked to a wide variety of pathologies. Previous studies suggested a discrepancy in age-associated telomere shortening rate estimated by cross-sectional studies versus the rate measured in longitudinal studies, indicating a potential bias in cross-sectional estimates. Intergenerational changes in initial telomere length, such as that predicted by the previously described effect of a father's age at birth of his offspring (FAB), could explain the discrepancy in shortening rate measurements. We evaluated whether changes occur in initial telomere length over multiple generations in three large datasets and identified paternal birth year (PBY) as a variable that reconciles the difference between longitudinal and cross-sectional measurements. We also clarify the association between FAB and offspring telomere length, demonstrating that this effect is substantially larger than reported in the past. These results indicate the presence of a downward secular trend in telomere length at birth over generational time with potential public health implications.
机译：总结随着年龄的增长，端粒的长度会缩短，端粒短与多种病理因素有关。先前的研究表明，横断面研究估计的年龄相关端粒缩短率与纵向研究中测得的比率存在差异，表明横断面估计值存在潜在偏差。端粒初始长度的代际变化，如先前描述的父亲在其后代出生时的影响（FAB）所预测的那样，可以解释缩短率测量中的差异。我们评估了三个大型数据集中多代人的初始端粒长度是否发生变化，并将父本出生年（PBY）确定为一个变量，以调节纵向和横截面测量之间的差异。我们还阐明了FAB与后代端粒长度之间的关联，表明这种作用远大于过去报道的结果。这些结果表明，随着年龄的增长，出生时端粒长度呈长期下降趋势，并可能对公共健康产生影响。

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