• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Applied Polymer Science >Agar/Chitosan IPN Thin Hydrogel Films with Antimicrobial and Antioxidant Properties for Potential Dressing Applications | Bentham Science
【24h】

Agar/Chitosan IPN Thin Hydrogel Films with Antimicrobial and Antioxidant Properties for Potential Dressing Applications | Bentham Science

机译：具有抗微生物和抗氧化特性的琼脂/壳聚糖IPN薄水凝胶薄膜，可用于潜在的敷料应用|边沁科学

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Polymeric films derived from natural sources biopolymers are promising materialsas wound dressing materials due to their biodegradable, biocompatible, non-toxic natures.Objective: To demonstrate the preparation of agar/chitosan thin hydrogel films for potential wounddressing applications.Method: The swelling and moisture content of hydrogel films at different pHs were determined. Also,their antioxidant properties via total phenol content, and ABTS+ scavenging assay methods were investigated.Antimicrobial properties against various bacteria and the cytotoxicity of the prepared hydrogelfilms were determined by means of WST-1 assay against L929 fibroblast cells.Results: The maximum swelling values of RA containing agar/0.17chitosan thin hydrogel films weredetermined as 255 ± 88%, 209 ± 41%, and 262 ± 31% at pH 5.4, 7.4, and 9, respectively. Also, themoisture contents at these pHs were also found as 79 ± 0.3%, 76 ± 1.3%, and 82 ± 0.9%, respectively.RA is found to enhance the antioxidant capacity prepared films with 17.99 mM trolox equivalencyg-1antioxidant capacity. Agar/0.33chi hydrogel film and its HCl treated forms are found effectively antimicrobialmaterials against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Candida albicansstrains with 10-5 mg mL-1 of MIC values. Moreover, agar and agar/0.33chi hydrogels were foundto use as safe, whereas agar/0.17chi/0.083RA hydrogel films were demonstrated good biocompatibilityagainst L929 fibroblast cells.Conclusion: Soft and flexible structure of agar/chi based hydrogel films afford great potential for openwounds as covering martials with high swelling ability and moisture content. These with RA materialspossess good antioxidant properties, and effectively antimicrobial properties and found biocompatibleagainst L929 fibroblast cells.
机译：背景：天然来源的生物聚合物聚合膜由于具有可生物降解，生物相容性，无毒的特性，因此有望作为伤口包扎材料。目的：证明琼脂/壳聚糖薄水凝胶膜的制备方法可用于潜在的创口应用。测定了在不同pH下水凝胶膜的水分含量。此外，还通过总苯酚含量和ABTS +清除方法研究了它们的抗氧化性能。通过WST-1测定法对L929成纤维细胞的抗菌性能和制备的水凝胶膜的细胞毒性。结果：最大溶胀值在pH 5.4、7.4和9下，将含有RA的琼脂/0.17壳聚糖薄水凝胶薄膜的含量分别确定为255±88％，209±41％和262±31％。同样，在这些pH值下的水分含量分别为79±0.3％，76±1.3％和82±0.9％。发现RA可以增强制备的具有17.99 mM trolox当量g-1抗氧化剂能力的薄膜的抗氧化能力。已发现琼脂/0.33chi水凝胶膜及其HCl处理形式可有效抵抗MIC，MIC值为10-5 mg mL-1的大肠杆菌，金黄色葡萄球菌，枯草芽孢杆菌和白色念珠菌菌株。此外，发现琼脂和琼脂/0.33chi水凝胶是安全的，而琼脂/0.17chi/0.083RA水凝胶膜被证明对L929成纤维细胞具有良好的生物相容性。结论：琼脂/ chi水凝胶膜的柔软而灵活的结构具有巨大的潜力openwounds具有较高的溶胀能力和水分含量，是一种覆盖武术。这些具有RA材料的材料具有良好的抗氧化性能，并具有有效的抗菌性能，并且与L929成纤维细胞具有生物相容性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号