• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >p(AAm/TA)-based IPN hydrogel films with antimicrobial and antioxidant properties for biomedical applications
【24h】

p(AAm/TA)-based IPN hydrogel films with antimicrobial and antioxidant properties for biomedical applications

机译：基于p（AAm / TA）的IPN水凝胶膜具有抗微生物和抗氧化特性，适用于生物医学应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Interpenetrating polymer networks (IPN), either semi-IPN (s-IPN) or full IPN, based on a natural polymer tannic acid (TA) and synthetic poly(acrylamide) (p(AAm)) were prepared by incorporation of TA during p(AAm) hydrogel film preparation with and without crosslinking of TA simultaneously. The synthesis of p(AAm/TA) s-IPN and IPN hydrogels with different amounts of TA were prepared by concurrent use of redox polymerization and epoxy crosslinking. The p(AAm)-based hydrogels were completely degraded at 37.5 degrees C within 9 and 2 days at pHs 7.4 and 9, respectively. Biocompatibility of p(AAm), s-IPN, and IPN were tested with WST assay and double staining, they had 75% cell viability up to almost 20 mu g mL(-1) concentration against L929 fibroblast cell. Antioxidant properties of IPN and s-IPN hydrogels were investigated with a:: and ABTS(-) methods. Antimicrobial properties of TA-containing s-IPN, and IPN hydrogels were determined against three common bacterial strains, Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, and Bacillus subtilis ATCC 6633, and it was found that p(AAm/TA)-based s-IPN and IPN hydrogels are effective antimicrobial and antioxidant materials. Moreover, almost up to day-long linear TA release profiles were obtained from IPN and s-IPN hydrogels in phosphate buffer solution at pH 7.4 at 37.5 degrees C. (C) 2015 Wiley Periodicals, Inc.
机译：互穿聚合物网络（IPN）是基于天然聚合物鞣酸（TA）和合成聚丙烯酰胺（p（AAm））的半IPN（s-IPN）或全IPN，方法是在p期间掺入TA （AAm）水凝胶薄膜制剂，可同时进行和不进行TA交联。同时使用氧化还原聚合和环氧交联反应制备了具有不同TA量的p（AAm / TA）s-IPN和IPN水凝胶。基于p（AAm）的水凝胶分别在97.5和2天内在pH 7.4和9下于37.5摄氏度下完全降解。 p（AAm），s-IPN和IPN的生物相容性已通过WST分析和双重染色进行了测试，它们对L929成纤维细胞的细胞活力高达75％，最高达20μg mL（-1）。使用a ::和ABTS（-）方法研究了IPN和s-IPN水凝胶的抗氧化性能。确定了含TA的s-IPN和IPN水凝胶对三种常见细菌菌株（大肠杆菌ATCC 8739，金黄色葡萄球菌ATCC 6538和枯草芽孢杆菌ATCC 6633）的抗菌特性，发现基于p（AAm / TA） s-IPN和IPN水凝胶是有效的抗菌和抗氧化剂材料。此外，从IPN和s-IPN水凝胶在pH 7.4、37.5摄氏度的IPN和s-IPN水凝胶中获得了近一天的线性TA释放曲线。（C）2015 Wiley Periodicals，Inc.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号