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首页> 外文期刊>Current Applied Polymer Science >Praziquantel Release Systems Based on Poly(Butylene Succinate)/Po lyethylene Glycol Nanocomposites | Bentham Science
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Praziquantel Release Systems Based on Poly(Butylene Succinate)/Po lyethylene Glycol Nanocomposites | Bentham Science

机译：聚丁二酸丁二醇酯/聚乙二醇纳米复合材料的吡喹酮释放系统边沁科学

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Background: Neglected diseases correspond to a group of infectious diseases that affect mainlythe poorest people and are not deeply researched. Among these neglected diseases, schistosomiasis standsout. The clinical course of this disease can vary from forms where there is no presence of symptoms, up toextremely severe cases, which lead to death. Praziquantel, PZQ, is the most common drug used for thetreatment of schistosomiasis, however, PZQ presents poor solubility and bioavailability.Objective: To overcome this problem, this work presents a new copolymer based on poly (butylenesuccinate), PBS, and polyethylene glycol 6000, PEG.Method: A composite based on this copolymer and organophilic nanoclay was prepared by in situ polycondensation,aiming to test the effect of the clay on the release profile of the drug. Samples were characterizedusing several techniques.Results: The results demonstrated that both the copolymer and the composite were able to increase thesolubility of the drug, making it fully available within the time period examined. Among the materialstested, the composite presented a more controlled release profile, allowing the entire drug to be availablein the dissolution medium for 72 h.Conclusions: The obtained results allowed the conclusion that composite systems based on PBS andPEG could be of great importance in the treatment of schistosomiasis, combining low cost and ease ofpreparation, enabling the use of lower doses of the drug, which could increase the efficiency of treatmentand the quality of life of people infected.
机译：背景：被忽视的疾病对应于一组传染病，主要影响最贫困的人群，并且没有深入研究。在这些被忽视的疾病中，血吸虫病表现突出。该疾病的临床病程可以从不存在症状的形式变化，甚至可以导致死亡的极端严重的情况。吡喹酮（PZQ）是用于治疗血吸虫病的最常用药物，但是，PZQ的溶解度和生物利用度较差。目的：为了克服这一问题，这项工作提出了一种基于聚丁二酸丁二酸酯，PBS和聚乙二醇6000的新型共聚物。方法：通过原位缩聚反应制备基于该共聚物和亲有机纳米粘土的复合材料，以测试粘土对药物释放特性的影响。使用多种技术对样品进行表征。结果：结果表明，共聚物和复合物均能够提高药物的溶解度，从而使其在所检查的时间内完全可用。在所测试的材料中，复合材料表现出更受控的释放特性，使整个药物在溶出介质中可使用72小时。结论：获得的结果可以得出结论，基于PBS和PEG的复合材料系统在治疗中可能具有重要意义结合血吸虫病的低成本和易于制备，可以使用较低剂量的药物，从而可以提高治疗效率和感染者的生活质量。

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