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首页> 外文期刊>Current Applied Polymer Science >Difference in Cell Adhesion on Three Biodegradable Aliphatic Polyesters | Bentham Science
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Difference in Cell Adhesion on Three Biodegradable Aliphatic Polyesters | Bentham Science

机译：三种可生物降解的脂肪族聚酯在细胞粘附上的差异边沁科学

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Background: Various aliphatic polyesters recently developed as biodegradable plastics arepotentially useful as bioresorbable polymers for biomedical application. In implanting biodegradabledevices in vivo, it is necessary to evaluate their biocompatibility, histocompatibility, and hemocompatibility.Objective: The relationship between the cell adhesion and proliferation and the protein adsorption onthree kinds of biodegradable aliphatic polyesters, poly(L-lactide) (PLLA), poly(3-[R]-hydroxybutyrate/valerate) ([R]-PHB/HV) and poly(butylene succinate-co-lactide) (PBSL) was investigated and comparedwith that on [RS]-PHB.Methods: The cell adhesion was evaluated with 3T3-L1 fibroblast, HeLa S3, and HUVECs (humanumbilical vein endothelial cells) cells on a polymer film of each polyester before and after protein adsorption.Results: The cells attached to the films of PLLA, PBSL and [R]-PHB/HV, whereas the cells attachedto [RS]-PHB kept a round shape. The cell adhesion of HeLa S3 was found to be similar to that of 3T3-L1 fibroblast cells, decreasing in the order of PLLA>PBSL>[R]-PHB/HV>[RS]-PHB. The opticalmicrographs of 3T3-L1 fibroblast and HeLa S3 cells attached on the film surfaces revealed that thecells were activated to undergo proliferation and extension of all the polymer films except the [RS]-PHB film. The HUVEC cells were also activated to induce proliferation and extension on the PLLAand PBSL films.Conclusion: The three cells were highly activated on each of the polyester films to undergo cell proliferationand extension, being different from the behavior of cells on [RS]-PHB. These data indicatedthat the biodegradable polyesters have excellent biocompatibility for use as scaffold materials in tissueengineering.
机译：背景技术：最近发展为可生物降解塑料的各种脂族聚酯潜在地可用作生物医学应用中的可生物吸收聚合物。在体内植入生物可降解装置时，有必要评估其生物相容性，组织相容性和血液相容性。目的：三种生物可降解脂肪族聚酯，聚L-丙交酯（PLLA）的细胞粘附和增殖与蛋白质吸附之间的关系。研究了聚[3- [R]-羟基丁酸酯/戊酸酯] [[R] -PHB / HV）和聚[丁二酸琥珀酸酯-共-丙交酯]（PBSL），并将其与[RS] -PHB进行比较。方法：细胞在蛋白质吸附之前和之后，分别在每种聚酯的聚合物膜上用3T3-L1成纤维细胞，HeLa S3和HUVEC（人脐静脉内皮细胞）细胞评估粘附性。结果：细胞附着在PLLA，PBSL和[R]膜上-PHB / HV，而附着在[RS] -PHB上的细胞则保持圆形。发现HeLa S3的细胞粘附与3T3-L1成纤维细胞相似，以PLLA> PBSL> [R] -PHB / HV> [RS] -PHB的顺序降低。贴在膜表面的3T3-L1成纤维细胞和HeLa S3细胞的光学显微照片显示，该细胞被激活以经历除[RS] -PHB膜以外的所有聚合物膜的增殖和延伸。结论：在聚酯薄膜上，三个细胞均被高度激活，以进行细胞增殖和延伸，这与[RS] -PHB上的细胞行为不同。 。这些数据表明，可生物降解的聚酯具有优异的生物相容性，可用作组织工程中的支架材料。

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