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首页> 外文期刊>American-Eurasian Journal of Agricultural and Environmental Sciences >Antimalarial Activity and Effect of Ethanol Extract of Pleiocarpa mutica Leaves on Some Haematological Indices of Plasmodium berghei -Infected Mice
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Antimalarial Activity and Effect of Ethanol Extract of Pleiocarpa mutica Leaves on Some Haematological Indices of Plasmodium berghei -Infected Mice

机译：苦竹叶的抗疟活性和乙醇提取物对伯氏疟原虫感染的小鼠某些血液学指标的影响

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The present study evaluated antimalarial activity and the effect of ethanol extract of Pleiocarpamutica leaves on some haematological indices of Plasmodium berghei -infected mice. A total of thirty mice(both infected (test) and non- infected (control)) consisting of six groups (of five mice each) were used in thestudy. Group 1 served as the negative control (non- parasitized), group 2 as the positive control (parasitizedbut not treated) and group 3, standard control (malaria- infected mice treated with artesunate). Groups 4, 5 and6 were malaria- infected mice treated with 200, 300 and 400 mg/kg body weight of the ethanol extract ofPleiocarpa mutica leaves respectively. The acute toxicity study of the extract showed that it is relatively safewith LD50 above 5000 mg/kg body weight. The phytochemical analysis of the Pleiocarpa mutica leavesrevealed its richness in bioactive components, most especially flavonoids, alkaloids and terpenoids which havebeen shown to possess antimalarial properties. No parasitaemia was observed in the negative control while itwas observed that there was a daily increase in percentage parasitaemia in the positive control group. However,there was a significant (p < 0.05), dose- dependent reduction in percentage parasitemia in the parasitized-treatedgroups when compared with the positive control as observed in day 2 and day 3 post- treatment. The decreasesin percentage parasitaemia observed in the extract-treated groups were comparable to that of group 3 (treatedwith standard antimalarial drug). The haematological analysis revealed that infection induced significant(p<0.05) decreases in packed cell volume (PCV), haemoglobin concentration (Hb), the white blood cell count(WBC) and red blood cell count (RBC) of the positive control group when compared to parasitized- treatedgroups. The findings suggest that P. mutica leaves have anti-malarial activity and ameliorative effects onaltered haematological indices in malaria parasite-infected mice.
机译：本研究评估了抗疟疾活性和苦竹叶乙醇提取物对感染伯氏疟原虫的小鼠某些血液学指标的影响。本研究共使用了六组（每组五只小鼠）组成的三十只小鼠（感染（测试）和未感染（对照））。第1组用作阴性对照（未寄生），第2组用作阳性对照（被寄生但未治疗），第3组标准对照（用青蒿琥酯治疗的疟疾感染小鼠）。第4、5和6组是分别用200、300和400mg / kg体重的苦竹叶的乙醇提取物处理的疟疾感染的小鼠。提取物的急性毒性研究表明，LD50高于5000 mg / kg体重时，它相对安全。苦竹的叶子的植物化学分析揭示了其对生物活性成分的丰富性，尤其是已显示具有抗疟疾特性的黄酮类，​​生物碱和萜类化合物。在阴性对照中未观察到寄生虫血症，而在阳性对照组中观察到寄生虫百分率每天都在增加。但是，与在治疗后第2天和第3天观察到的阳性对照相比，在被寄生虫处理的组中，寄生虫百分率显着（p <0.05）剂量依赖性降低。在提取物治疗组中观察到的寄生虫百分率降低与第三组（用标准抗疟药治疗）相当。血液学分析表明，感染后阳性对照组的包装细胞体积（PCV），血红蛋白浓度（Hb），白细胞计数（WBC）和红细胞计数（RBC）明显降低（p <0.05）。与寄生虫治疗组相比。这些发现表明，在疟原虫感染的小鼠中，变形假单胞菌叶具有抗疟活性和改善血液学指标的改善作用。

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