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首页> 外文期刊>Anais da Academia Brasileira de Ciencias >Effect of l-glutamine on myenteric neuron and of the mucous of the ileum of diabetic rats
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Effect of l-glutamine on myenteric neuron and of the mucous of the ileum of diabetic rats

机译：谷氨酰胺对糖尿病大鼠肠神经元和回肠黏膜的影响

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摘要

The objective of this work was to investigate the effect of the L-glutamine supplementation to prevent - diabetes induced changes in myenteric neurons and also to verify the effect on the mucosa of the ileum of Wistar rats. The animals were divided in five groups (n = 5): untreated normoglycaemic (UN), normoglycaemic treated with L-glutamine (NG), untreated diabetics (UD), diabetics treated with L-glutamine, starting on the 4th (DG4) or 45thday following diabetes induction (DG45). The amino acid was added to the diet at 1%. The density and size of neurons, the metaphasic index in the crypt, the height of the villus, the depth of the crypt and the number of globet cells were determined. There was no difference in the neuronal density and in the cellular body area of the myosin-stained myenteric neurons of groups DG4 and DG45 when compared to group D. The metaphase index and the number of goblet cells showed no significant differences when all groups were compared (P 0.05). The villi height of groups DG4 and DG45 were 45.5% (P 0.05) and 32.4% (P 0.05) higher than those in group UD, respectively. The analyzed crypts showed similar depth for all studied groups.
机译：这项工作的目的是研究补充L-谷氨酰胺预防糖尿病引起的肌间神经元变化的作用，并验证对Wistar大鼠回肠粘膜的作用。将动物分为四组（n = 5）：未治疗的正常血糖（UN），用L-谷氨酰胺（NG）治疗的正常血糖，未治疗的糖尿病患者（UD），用L-谷氨酰胺治疗的糖尿病患者，从第4天开始（DG4）或诱导糖尿病后第45天（DG45）。将氨基酸以1％的量添加到饮食中。确定了神经元的密度和大小，隐窝的中期相指数，绒毛的高度，隐窝的深度和地球细胞的数量。与D组相比，DG4和DG45组的肌球蛋白染色的肠系膜神经元的神经元密度和细胞体面积没有差异。比较所有组时，中期指数和杯状细胞的数量均无显着差异。 （P＞ 0.05）。 DG4组和DG45组的绒毛高度分别比UD组的绒毛高度高45.5％（P <0.05）和32.4％（P> 0.05）。所有研究组的隐窝均显示出相似的深度。

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