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首页> 外文期刊>Annals of Maxillofacial Surgery >Carcinoma arising in the background of oral submucous fibrosis
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Carcinoma arising in the background of oral submucous fibrosis

机译：口腔粘膜下纤维化背景下的癌

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Introduction: Oral submucous fibrosis is a chronic debilitating condition with potential for malignant transformation. Squamous cell carcinoma arising from a background of oral submucous fibrosis presents clinically as a distinct disease due to different etiopathogenesis. Methodology: This prospective case series describes thirty cases of oral squamous cell carcinoma (OSCC) alongside oral submucous fibrosis (OSF). Patient clinical data were recorded including type and duration of habits, site of tumor, size, histological grading and nodal status. Results: A total of 76% cases were reported in males and 24% in females. A total of 73.3% cases had a history of use of gutka of which 16% used only arecanut or gutka while the remaining used gutka along with smoking and quid habits and 26.7% cases smoked tobacco products or used smokeless tobacco. Primary site of presentation was buccal mucosa and seven cases of carcinoma at retromolar trigone (RMT) altogether accounting for 66% of the cases. 53.3% cases reported were advanced tumour T4 lesions, 10% T3 lesion, 30% reported as T2 lesions and 6.7% T1 lesion. 55% of cases showed nodal involvement of different level and 46.5% cases were N0. About 60% of cases were histologically well differentiated squamous cell carcinoma. Conclusion: Carcinoma arising from a background of oral submucous fibrosis follows a distinct clinical presentation. Malignant transformation occurs in younger age group and with better histological grading.
机译：简介：口腔粘膜下纤维化是一种慢性衰弱性疾病，可能发生恶性转化。由口腔粘膜下纤维化的背景引起的鳞状细胞癌在临床上由于不同的病因而表现为独特的疾病。方法：此前瞻性病例系列描述了30例口腔鳞状细胞癌（OSCC）以及口腔粘膜下纤维化（OSF）。记录患者临床数据，包括习惯类型和持续时间，肿瘤部位，大小，组织学分级和淋巴结状态。结果：总共报告了76％的病例，男性为2​​4％，女性为24％。共有73.3％的病例有使用古特卡的病史，其中16％的仅使用槟榔或古特卡，而其余的使用过的古特卡以及吸烟和乌贼习惯，以及26.7％的烟熏产品或二手烟。表现的主要部位是颊黏膜，在后磨牙三角区（RMT）共7例癌变，占病例的66％。报告的病例中，有53.3％为晚期T4病变，10％为T3病变，30％为T2病变和6.7％T1病变。 55％的病例显示不同程度的淋巴结受累，N0为46.5％。约60％的病例是组织学上分化良好的鳞状细胞癌。结论：由口腔粘膜下纤维化背景引起的癌具有明显的临床表现。恶性转化发生在较年轻的人群中，组织学分级更高。

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