Determination of Acid Dissociation Constants of Compounds Active at Neuronal Nicotinic Acetylcholine Receptors by Means of Electrophoretic and Potentiometric Techniques

Gabriella RODA; Clelia DALLANOCE; Giovanni GRAZIOSO; Vincenzo LIBERTI; Marco De AMICI

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Determination of Acid Dissociation Constants of Compounds Active at Neuronal Nicotinic Acetylcholine Receptors by Means of Electrophoretic and Potentiometric Techniques

机译：电泳和电位技术测定在神经元烟碱乙酰胆碱受体上有活性的化合物的酸解离常数

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The dissociation constants of epiboxidine 2 and a series of bases active at neuronal nicotinic acetylcholine receptors were determined by means of potentiometric and electrophoretic methods, which gave values in good agreement. Although showing different features, the two techniques are complementary for dissociation constant determinations. The choice of the most suitable method is guided by the available amount of sample, its purity, and the time needed for the analysis. The experimental values were compared with the predictions obtained with ACD/pK _(a) DB software.

机译：通过电位法和电泳法测定了epiboxidine b 2的解离常数和对神经元烟碱乙酰胆碱受体有活性的一系列碱基的解离常数，其值具有良好的一致性。尽管显示出不同的特征，但这两种技术对于解离常数测定是互补的。选择最合适的方法取决于样品的可用量，其纯度和分析所需的时间。将实验值与使用ACD / p K_（a）DB软件获得的预测值进行比较。

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《Analytical Sciences》 |2010年第1期|共4页
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Gabriella RODA; Clelia DALLANOCE; Giovanni GRAZIOSO; Vincenzo LIBERTI; Marco De AMICI;
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中图分类分析化学;
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7. Determination of Acid Dissociation Constants of Compounds Active at Neuronal Nicotinic Acetylcholine Receptors by Means of Electrophoretic and Potentiometric Techniques [O] . Gabriella RODA, Clelia DALLANOCE, Giovanni GRAZIOSO, 2010

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Determination of Acid Dissociation Constants of Compounds Active at Neuronal Nicotinic Acetylcholine Receptors by Means of Electrophoretic and Potentiometric Techniques

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