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首页> 外文期刊>Analytical Sciences >LC-MS/MS Analysis of Diarrhetic Shellfish Poisoning (DSP) Toxins, Okadaic Acid and Dinophysistoxin Analogues, and Other Lipophilic Toxins
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LC-MS/MS Analysis of Diarrhetic Shellfish Poisoning (DSP) Toxins, Okadaic Acid and Dinophysistoxin Analogues, and Other Lipophilic Toxins

机译：腹泻性贝类毒素（DSP）毒素，冈田酸和Dinophysistoxin类似物以及其他亲脂性毒素的LC-MS / MS分析

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摘要

Diarrhetic shellfish poisoning (DSP) is a severe gastrointestinal illness caused by consumption of shellfish contaminated with DSP toxins that are originally produced by toxic dinoflagellates. Based on their structures, DSP toxins were initially classified into three groups, okadaic acid (OA)/dinophysistoxin (DTX) analogues, pectenotoxins (PTXs), and yessotoxins (YTXs). Because PTXs and YTXs have been subsequently shown to have no diarrhetic activities, PTXs and YTXs have recently been eliminated from the definition of DSP toxins. Mouse bioassay (MBA), which is the official testing method of DSP in Japan and many countries, also detects PTXs and YTXs, and thus alternative testing methods detecting only OA/DTX analogues are required in DSP monitoring. Electrospray ionization (ESI) liquid chromatography–mass spectrometry (LC-MS) is a very powerful tool for the detection, identification and quantification of DSP and other lipophilic toxins. In the present review, application of ESI LC-MS techniques to the analysis of each toxin group is described.
机译：腹泻性贝类中毒（DSP）是一种严重的胃肠道疾病，原因是食用被DSP毒素污染的贝类，而贝类毒素最初是由有毒的鞭毛虫产生的。根据其结构，DSP毒素最初分为三类：冈田酸（OA）/恐龙物理毒素（DTX）类似物，果胶毒素（PTXs）和野毒素（YTXs）。由于随后已显示PTX和YTX没有腹泻活性，因此最近从DSP毒素的定义中删除了PTX和YTX。鼠标生物测定法（MBA）是日本和许多国家/地区DSP的官方测试方法，它也可以检测PTX和YTX，因此在DSP监测中仅需要检测OA / DTX类似物的替代测试方法是必需的。电喷雾电离（ESI）液相色谱-质谱（LC-MS）是检测，鉴定和定量DSP和其他亲脂性毒素的非常强大的工具。在本综述中，描述了ESI LC-MS技术在每个毒素组分析中的应用。

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