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首页> 外文期刊>Annual Research & Review in Biology >Early Prenatal Stress Increases Body Weight and Reduces Nociception in Adult Male Rats
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Early Prenatal Stress Increases Body Weight and Reduces Nociception in Adult Male Rats

机译：产前早期应激会增加成年雄性大鼠的体重并减少伤害感受

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Aims: Behavioral responses of 3-month-old male pups from female Wistar rats exposed to daily 1 hour or 3 hour restraint stress during the first 7 days of pregnancy were studied by tail flick and formalin test. Methodology: Eighteen mature virgin female albino rats (140g-160g) were randomly allocated in a blinded fashion to 3 groups (n=6 each) and mated. Group 1 rats were the control and did not undergo restraint stress. Groups 2 and 3 rats were restrained for 1 hour and 3 hours respectively during the first 7 days of pregnancy. Six male rats only served purpose of copulation. At 3 month of age, 34 pups consisting of 10, 11 and 13 pups delivered by rats in groups 1, 2 and 3 respectively were randomly selected and studied for nociception. Results: Body weights were higher in both 1 hour and 3 hour prenatally stressed pups compared to that of the control. The latency period during the tail immersion test in the pups prenatally stressed for 3 hour daily but not those stressed for 1 hour daily was significantly higher (p<0.05) compared to that of control. While there were no significant differences in the formalin score in pups prenatally stressed for 1 hour and 3 hour compared to the score of the control during the early phase, the formalin score of the pups prenatally stressed for 3 hour daily but not those stressed for 1 hour daily was significantly lower compared to that of the control during the late phase. Conclusion: Our findings suggest that early prolonged prenatal stress modulates nociceptive sensitivity in 3-month-old rat and that different mechanisms are responsible for the effects of prenatal stress on acute and persistent pain in the formalin test.
机译：目的：通过甩尾和福尔马林试验研究来自雌性Wistar大鼠的3个月大的幼崽在怀孕前7天每天暴露于1小时或3小时约束压力下的行为反应。方法：18只成年雌性白化病成年雌性大鼠（140g-160g）以盲法随机分为3组（每组6只）并交配。第1组大鼠为对照组，没有束缚压力。第2组和第3组大鼠在怀孕的前7天分别被束缚1小时和3小时。六只雄性大鼠仅用于交配。在3个月大时，随机选择由第1、2和3组的大鼠递送的34只幼崽，分别由10只，11只和13只幼崽组成，并研究其伤害感受。结果：与对照组相比，产前压力大的幼犬在1小时和3小时内体重均较高。与对照组相比，在产前每天压力为3小时的幼犬的尾巴浸没测试中的潜伏期显着更高（p <0.05），而每天压力不超过1小时的幼犬。虽然与早期对照组的分数相比，产前压力为1小时和3小时的幼犬的福尔马林分数没有显着差异，但产前压力为3小时的幼犬的福尔马林分数却为每日1次与后期相比，每天的小时数明显低于对照组。结论：我们的发现表明，早产前长期应激会调节3个月大大鼠的伤害感受敏感性，并且在福尔马林测试中，不同的机制可导致产前应激对急性和持续性疼痛的影响。

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