The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli

Hayriye Gen?; O??uz Karabay

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The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli

机译：2-氨基茚满双胍氯化物和乙酸盐对耐药革兰氏阴性杆菌的抗菌活性

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Antiseptics and disinfectants are important substances for medical care. However, the needs for new antiseptics have increased in the last few years, due to multi-drug resistant pathogens. In this study we aimed to evaluate, the efficacy of 2-aminoindanbiguanide chloride (2-AIB.HCI) and 2-aminoindanbiguanideacetate (2-AIB.HOAc) salts that were synthesized against multi-drug resistant Gram-negative bacilli (MDR-GNB) ( Acinetobacter spp, Escherichia coli and Klebsiella pneumoniae ). According to our resultsat70 mg/mL concentrations of 2-AIB.HCI and 2-AIB.HOAc salts have been confirmed to be effective against hospital infection causing MDR-GNB. It was shown that 2-AIB.HCI and 2-AIB.HOAc salts have antibacterial efficacy against MDR-GNB.

机译：防腐剂和消毒剂是用于医疗的重要物质。但是，由于具有多重耐药性的病原体，最近几年对新型抗菌剂的需求增加了。在这项研究中，我们旨在评估2-氨基茚满双胍氯化物（2-AIB.HCI）和2-氨基茚满双胍乙酸盐（2-AIB.HOAc）盐对多药耐药革兰氏阴性杆菌（MDR-GNB）合成的功效。）（不动杆菌属，大肠埃希菌和肺炎克雷伯菌）。根据我们的结果，已确认70 mg / mL浓度的2-AIB.HCl和2-AIB.HOAc盐可有效抵抗引起MDR-GNB的医院感染。结果表明2-AIB.HCl和2-AIB.HOAc盐具有抗MDR-GNB的抗菌作用。

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《Annual Research & Review in Biology》 |2014年第9期|共8页
作者
Hayriye Gen?; O??uz Karabay;
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中图分类普通生物学;
关键词
Multi-drugresistantbacteriadisinfectantdisinfection2-aminoindanbiguanide salts.;

机译：多药耐药性细菌消毒剂2-氨基茚满双胍盐。;

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The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli

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