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首页> 外文期刊>Annual Review & Research in Biology >Effects of Oral and Dermal Sub-Chronic Exposure of Kerosene on Biochemical Parameters in Male Wistar Rats
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Effects of Oral and Dermal Sub-Chronic Exposure of Kerosene on Biochemical Parameters in Male Wistar Rats

机译：口腔和皮肤亚慢性暴露于煤油对雄性Wistar大鼠生化指标的影响

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Aim: Many of the studies that have been carried out to investigate the toxicity of kerosene have been large-dose, acute-setting experiments. Although the hepatic and renal damage as a result of kerosene exposure has been demonstrated in an earlier study in female Wistar rats, gender is known to play a role in an animal’s response to a xenobiotic. Therefore, the aim of this study is to determine the effect of repeated exposure of trace amount of kerosene to male Wistar rats so as to establish if differences in gender of an animal will modulate the toxic response of kerosene in sub-chronic setting. Methods: Twelve male rats were divided equally into 2 groups and administered with 0.4 ml/kg kerosene either through the oral or dermal route; six other rats served as control group. Kerosene administration lasted for 21 days after which blood was obtained through retro-orbital bleeding. Results: Results of the study reveal that while the hepatic enzymes alanine aminotransferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP) and γ-glutamyl transferase (γ-GT) as well as other biochemical parameters- bilirubin, urea, creatinine and uric acid were significantly increased, total protein and albumin were significantly reduced (p<0.05). Moreover, in most cases these changes were more significant for oral route than dermal route. Conclusion: These results suggest nephrotoxic and hepatotoxic nature of kerosene in male rats and confirm that the oral route of administration is more dangerous than dermal, a finding that was similar to what was observed for female rats in an earlier study.
机译：目的：已经进行的许多研究煤油毒性的研究都是大剂量的急性实验。尽管较早的一项研究在雌性Wistar大鼠中证明了由于煤油暴露而造成的肝和肾损害，但已知性别在动物对异种生物的反应中起作用。因此，本研究的目的是确定雄性Wistar大鼠反复接触痕量煤油的效果，从而确定动物的性别差异是否会调节亚慢性环境下的煤油毒性反应。方法：将12只雄性大鼠平均分为2组，通过口服或经皮途径给予0.4 ml / kg的煤油。另外六只大鼠作为对照组。煤油施用持续21天，之后通过眼眶后出血获得血液。结果：研究结果表明，虽然肝酶中的丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），碱性磷酸酶（ALP）和γ-谷氨酰转移酶（γ-GT）以及其他生化参数-胆红素，尿素，肌酐和尿酸显着增加，总蛋白和白蛋白显着降低（p <0.05）。此外，在大多数情况下，口服途径的这些变化比皮肤途径的显着。结论：这些结果表明，煤油对雄性大鼠具有肾毒性和肝毒性，并证实口服给药比经皮给药更危险，这一发现与早期研究中对雌性大鼠观察到的相似。

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