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首页> 外文期刊>Annual Research & Review in Biology >Mesenchymal Stem Cell-based Cancer Gene Therapy: Application and Unresolved Problems
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Mesenchymal Stem Cell-based Cancer Gene Therapy: Application and Unresolved Problems

机译：间充质干细胞癌基因治疗：应用和未解决的问题

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摘要

There are many barriers that have hindered the progress of clinical application of gene therapy as a potential method for treating cancer. These limitations are caused by transduction/delivery failure rates with viral vector systems and were due to the resultant non-specific targeting as well as the triggering of immune system stimulation. Recently, mesenchymal stem cells (MSCs) were found to be advantageous in improving tumor tropism as well as in providing an immune-privilege. Therefore, the combination of viral vector systems and stem cells was suggested as an attractive solution to promote targeted-delivery of anticancer therapeutics to tumor sites. In this regard, many published studies have shown that MSCs could be useful as a potential vehicle for delivering anticancer agents to tumors. In this review, the disadvantages of viral vector systems for gene therapy were analyzed, and an updated account on the role of MSCs in cancer gene therapy was presented. In addition, major safety and therapeutic unresolved problems facing this approach in clinical application were also addressed.
机译：有许多障碍阻碍了基因治疗作为治疗癌症的潜在方法的临床应用的进展。这些限制是由病毒载体系统的转导/传递失败率引起的，并且归因于所产生的非特异性靶向以及免疫系统刺激的触发。最近，发现间充质干细胞（MSC）在改善肿瘤嗜性以及提供免疫特权方面是有利的。因此，病毒载体系统和干细胞的组合被认为是促进抗癌治疗剂靶向递送至肿瘤部位的有吸引力的解决方案。在这方面，许多已发表的研究表明，MSCs可用作将抗癌药递送至肿瘤的潜在载体。在这篇综述中，分析了病毒载体系统用于基因治疗的弊端，并提供了有关MSC在癌症基因治疗中作用的最新资料。此外，还解决了该方法在临床应用中面临的主要安全性和未解决的治疗问题。

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