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首页> 外文期刊>Antibiotics >Anti-Adhesion Activity of A2-type Proanthocyanidins (a Cranberry Major Component) on Uropathogenic E. coli and P. mirabilis Strains
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Anti-Adhesion Activity of A2-type Proanthocyanidins (a Cranberry Major Component) on Uropathogenic E. coli and P. mirabilis Strains

机译：A2型原花色素（蔓越莓的主要成分）对致病性大肠杆菌和奇异假单胞菌菌株的抗黏附活性

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Urinary tract infections (UTIs) are relatively common in women and may be classified as uncomplicated or complicated, depending upon the urinary tract anatomy and physiology. Acute uncomplicated cystitis (AUC) occurs when urinary pathogens from the bowel or vagina colonize the periurethral mucosa and reach the bladder. The vast majority of episodes in healthy women involving the same bacterial strain that caused the initial infection are thought to be reinfections. About 90% of AUC are caused by uropathogenic Escherichia coli (UPEC), but Proteus mirabilis also plays an important role. Several studies support the importance of cranberry (Vaccinium macrocarpon) proanthocyanidins in preventing adhesion of P-fimbriated UPEC to uroepithelial cells. In this study, we evaluated the in vitro anti-adhesion activity of A2-linked proanthocyanidins from cranberry on a UPEC and Proteus mirabilis strains and their possible influence on urease activity of the latter. A significant reduction of UPEC adhesion (up to 75%) on the HT1376 cell line was observed vs. control. For the strains of P. mirabilis there was also a reduction of adhesion (up to 75%) compared to controls, as well as a reduction in motility and urease activity. These results suggest that A2-type cranberry proanthocyanidins could aid in maintaining urinary tract health.
机译：尿路感染（UTI）在女性中相对普遍，根据尿路的解剖学和生理学，可分为简单性或复杂性。当来自肠道或阴道的尿液病原体定居在尿道周围粘膜并到达膀胱时，就会发生急性单纯性膀胱炎（AUC）。健康女性中涉及引起最初感染的同一细菌菌株的绝大多数发作被认为是再感染。大约90％的AUC是由尿路致病性大肠杆菌（UPEC）引起的，但是奇异变形杆菌也起着重要的作用。几项研究支持蔓越莓（Vaccinium macrocarpon）原花色素在防止P纤维化UPEC与尿道上皮细胞粘附方面的重要性。在这项研究中，我们评估了蔓越莓中A2连接的原花色素对UPEC和Proteus mirabilis菌株的体外抗黏附活性及其对后者脲酶活性的可能影响。与对照相比，观察到HT1376细胞系上的UPEC粘附力显着降低（高达75％）。与对照相比，对于奇异假单胞菌菌株，其粘附力也降低了（高达75％），并且运动性和脲酶活性也降低了。这些结果表明，A2型蔓越莓原花青素可以帮助维持尿道健康。

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