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首页> 外文期刊>Anuario de Psicologia Juridica >Lipid-based core-shell nanoparticles: Evolution and potentialities in drug delivery
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Lipid-based core-shell nanoparticles: Evolution and potentialities in drug delivery

机译：基于脂质的核-壳纳米颗粒：药物递送的演变和潜力

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Over the last decade, impressive progress in the field of nanomedicine has led to the development of novel biomaterials and nanotechnology platforms. However, lipid-based nanovectors, i.e. liposomes, combining safety, versatility and delivery efficiency, remain the most “popular” approach. Lipids, especially charged lipids, have been used to design nanoparticles characterized by a core-shell structure. In these nanoparticles a lipid shell interacts with a core based on different biomaterials. Drugs characterized by a net charge can be condensed in the core, which is then covered by the lipid shell. This approach has been investigated in relation to the delivery of different active molecules, among them macromolecular drug, e.g. nucleic acids, and small molecules, e.g. bisphosphonates. This review reports the progress that has been made in the development of this technology and its potential applications in drug delivery.
机译：在过去的十年中，纳米医学领域取得了令人瞩目的进步，导致了新型生物材料和纳米技术平台的发展。然而，结合安全性，多功能性和递送效率的基于脂质的纳米载体，即脂质体，仍然是最“流行”的方法。脂质，特别是带电荷的脂质，已被用于设计以核-壳结构为特征的纳米颗粒。在这些纳米颗粒中，脂质壳与基于不同生物材料的核心相互作用。以净电荷为特征的药物可以在核心中浓缩，然后被脂质壳覆盖。已经针对不同活性分子的递送研究了这种方法，其中包括大分子药物，例如大分子药物。核酸和小分子，例如双膦酸盐。这篇综述报告了该技术的发展及其在药物输送中的潜在应用。

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