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Clinical Efficacy of a Single Two Gram Dose of Azithromycin Extended Release for Male Patients with Urethritis

机译：单剂量两克阿奇霉素缓释对男性尿道炎患者的临床疗效

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To clarify the clinical efficacy of a single oral 2 g dose of azithromycin extended-release for heterosexual male patients with urethritis, and the current antimicrobial sensitivity of Neisseria gonorrhoeae to azithromycin, a prospective clinical trial was conducted from 2011–2013. In patients with gonococcal urethritis, the eradication rate was 90.9% (30 of 33). The susceptibility rates of isolated Neisseria gonorrhoeae strains to ceftriaxone, spectinomycin, cefixime and azithromycin were 100%, 100%, 95.3% (41/43) and 37.2% (16/43), respectively. In the patients with nongonococcal urethritis, the eradication rate was 90.0% (45 of 50). The microbiological eradication rates for the pathogens were 90.9% (30/33) for Neisseria gonorrhoeae, 91.5% (43/47) for Chlamydia trachomatis, 71.4% (5/7) for Mycoplasma genitalium, and 100% (13/13) for Ureaplasma urealyticum. The main adverse event was diarrhea and its manifestation rate was 35.2% (32 of 120). The symptom of diarrhea was mostly temporary and resolved spontaneously. The conclusion was that the treatment regimen with a single oral 2 g dose of azithromycin extended-release would be effective for patients with urethritis. However, the antimicrobial susceptibilities of Neisseria gonorrhoeae and Mycoplasma genitalium should be carefully monitored because of possible treatment failure.
机译：为阐明单次口服2 g阿奇霉素缓释对异性恋男性尿道炎患者的临床疗效，以及淋病奈瑟氏球菌对阿奇霉素的当前抗菌敏感性，于2011-2013年进行了一项前瞻性临床试验。在淋球菌性尿道炎患者中，根除率为90.9％（33中的30）。分离的淋病奈瑟氏球菌菌株对头孢曲松，壮观霉素，头孢克肟和阿奇霉素的敏感性分别为100％，100％，95.3％（41/43）和37.2％（16/43）。在非淋菌性尿道炎患者中，根除率为90.0％（50/45）。淋病奈瑟菌的病原体微生物根除率为90.9％（30/33），沙眼衣原体为91.5％（43/47），生殖器支原体为71.4％（5/7），生殖器为100％（13/13）。解脲脲原体。主要不良事件为腹泻，其表现率为35.2％（120中的32）。腹泻的症状主要是暂时的，可以自发缓解。结论是单次口服2 g阿奇霉素缓释剂的治疗方案对尿道炎患者有效。但是，由于可能的治疗失败，应仔细监测淋病奈瑟氏球菌和生殖支原体的抗菌药敏感性。

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