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Antimicrobial Stewardship and Urinary Tract Infections

机译:抗菌素管理和尿路感染

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Urinary tract infections are the most common bacterial infections encountered in ambulatory and long-term care settings in the United States. Urine samples are the largest single category of specimens received by most microbiology laboratories and many such cultures are collected from patients who have no or questionable urinary symptoms. Unfortunately, antimicrobials are often prescribed inappropriately in such patients. Antimicrobial use, whether appropriate or inappropriate, is associated with the selection for antimicrobial-resistant organisms colonizing or infecting the urinary tract. Infections caused by antimicrobial-resistant organisms are associated with higher rates of treatment failures, prolonged hospitalizations, increased costs and mortality. Antimicrobial stewardship consists of avoidance of antimicrobials when appropriate and, when antimicrobials are indicated, use of strategies to optimize the selection, dosing, route of administration, duration and timing of antimicrobial therapy to maximize clinical cure while limiting the unintended consequences of antimicrobial use, including toxicity and selection of resistant microorganisms. This article reviews successful antimicrobial stewardship strategies in the diagnosis and treatment of urinary tract infections.
机译:尿路感染是在美国的门诊和长期护理环境中最常见的细菌感染。尿液样本是大多数微生物学实验室收到的最大的一类标本,许多此类培养物是从没有或有可疑泌尿症状的患者那里收集的。不幸的是,在此类患者中经常不适当地开具抗菌药物。抗菌药物的使用,无论适当与否,都与选择定植或感染尿路的抗微生物生物有关。由抗药性微生物引起的感染与治疗失败率更高,住院时间延长,成本和死亡率增加相关。抗菌素管理包括在适当情况下避免使用抗菌素,并在指出抗菌剂时使用策略来优化抗菌素治疗的选择,剂量,给药途径,持续时间和时机,以最大程度地提高临床治愈率,同时限制抗菌素使用的意外后果,包括毒性和抗性微生物的选择。本文概述了在尿路感染的诊断和治疗中成功的抗菌素管理策略。

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