• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Antibiotics >Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions
【24h】

Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions

机译：厌氧条件下细菌对小鼠Paneth细胞α-防御素的敏感性差异

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Small intestinal Paneth cells secrete α-defensin peptides, termed cryptdins (Crps) in mice, into the intestinal lumen, where they confer immunity to oral infections and define the composition of the ileal microbiota. In these studies, facultative bacteria maintained under aerobic or anaerobic conditions displayed differential sensitivities to mouse α-defensins under in vitro assay conditions. Regardless of oxygenation, Crps 2 and 3 had robust and similar bactericidal activities against S. typhimurium and S. flexneri, but Crp4 activity against S. flexneri was attenuated in the absence of oxygen. Anaerobic bacteria varied in their susceptibility to Crps 2-4, with Crp4 showing less activity than Crps 2 and 3 against Enterococcus faecalis, and Bacteroides fragilis in anaerobic assays, but Fusobacterium necrophorum was killed only by Crp4 and not by Crps 2 and 3. The influence of anaerobiosis in modulating Crp bactericidal activities in vitro suggests that α-defensin effects on the enteric microbiota may be subject to regulation by local oxygen tension.
机译：小肠Paneth细胞在小鼠的肠腔内分泌被称为cryptdins（Crps）的α-防御素肽，在肠腔中，它们对口腔感染具有免疫力并确定回肠菌群的组成。在这些研究中，在需氧或厌氧条件下维持的兼性细菌在体外测定条件下对小鼠α-防御素的敏感性不同。不论氧合作用如何，Crps 2和Crp 3对鼠伤寒沙门氏菌和弗氏链球菌都有强大而相似的杀菌活性，但是在没有氧气的情况下，Crp4对弗氏链球菌的活性减弱了。厌氧细菌在粪便中对Crps 2-4的敏感性各不相同，Crp4在粪便肠球菌和脆弱拟杆菌中的活性比Crps 2和3弱，但坏死镰刀菌仅由Crp4杀死，而不由Crps 2和3杀死。厌氧菌对体外Crp杀菌活性的影响表明α-防御素对肠道菌群的作用可能受局部氧张力的调节。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号