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首页> 外文期刊>Antibiotics >Participation of S. Typhimurium cysJIH Operon in the H2S-mediated Ciprofloxacin Resistance in Presence of Sulfate as Sulfur Source
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Participation of S. Typhimurium cysJIH Operon in the H2S-mediated Ciprofloxacin Resistance in Presence of Sulfate as Sulfur Source

机译：硫酸盐作为硫源时鼠伤寒沙门氏菌cysJIH操纵子参与H 2 S介导的环丙沙星耐药性

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H2S production has been proposed as a mechanism to explain bacterial resistance to antibiotics. In this work, we present evidence for the role of the cysJIH operon in resistance to ciprofloxacin mediated by H2S production with different sulfate as the only sulfur source. We found that the products of the cysJIH operon are involved in ciprofloxacin resistance by increasing both, the levels of H2S and reduced thiols apparently counteracting antimicrobial-induced reactive oxygen species (ROS). This protective effect was observed only when bacteria were cultured in the presence of sulfate, but not with cysteine, as the sole sulfur source.
机译：有人提出以H 2 S作为解释细菌对抗生素耐药性的机制。在这项工作中，我们提供了cysJIH操纵子在以不同硫酸盐为唯一硫源的H 2 S产生介导的环丙沙星耐药性中的作用的证据。我们发现，cysJIH操纵子的产物通过增加H 2 S的水平和硫醇的减少均与环丙沙星耐药有关，这显然抵消了抗菌素诱导的活性氧（ROS）。仅当细菌在硫酸盐存在下培养而不是半胱氨酸作为唯一的硫源培养时才观察到这种保护作用。

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