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首页> 外文期刊>Applied Nanoscience >Antimicrobial activity of zinc and titanium dioxide nanoparticles against biofilm-producing methicillin-resistant Staphylococcus aureus
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Antimicrobial activity of zinc and titanium dioxide nanoparticles against biofilm-producing methicillin-resistant Staphylococcus aureus

机译：锌和二氧化钛纳米颗粒对产生生物膜的耐甲氧西林金黄色葡萄球菌的抗菌活性

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major nosocomial pathogens responsible for a wide spectrum of infections and the emergence of bacterial resistance to antibiotics has lead to treatment drawbacks towards large number of drugs. Formation of biofilms is the main contributing factor to antibiotic resistance. The development of reliable processes for the synthesis of zinc oxide nanoparticles is an important aspect of nanotechnology today. Zinc oxide and titanium dioxide nanoparticles comprise well-known inhibitory and bactericidal effects. Emergence of antimicrobial resistance by pathogenic bacteria is a major health problem in recent years. This study was designed to determine the efficacy of zinc and titanium dioxide nanoparticles against biofilm producing methicillin-resistant S. aureus . Biofilm production was detected by tissue culture plate method. Out of 30 MRSA isolates, 22 isolates showed strong biofilm production and 2 showed weak and moderate biofilm formation. Two strong and weak biofilm-producing methicillin-resistant S. aureus isolates were subjected to antimicrobial activity using commercially available zinc and titanium dioxide nanoparticles. Thus, the nanoparticles showed considerably good activity against the isolates, and it can be concluded that they may act as promising, antibacterial agents in the coming years
机译：耐甲氧西林的金黄色葡萄球菌（MRSA）是引起广泛感染的主要医院病原体之一，细菌对抗生素的耐药性的出现导致治疗药物趋向于大量使用。生物膜的形成是引起抗生素抗性的主要因素。发展可靠的合成氧化锌纳米粒子的方法是当今纳米技术的重要方面。氧化锌和二氧化钛纳米粒子具有众所周知的抑制作用和杀菌作用。近年来，病原菌对抗菌素的耐药性成为主要的健康问题。本研究旨在确定锌和二氧化钛纳米粒子对生物膜产生耐甲氧西林金黄色葡萄球菌的功效。通过组织培养板法检测生物膜的产生。在30个MRSA分离株中，有22个分离株显示出强大的生物膜产生，而2个分离株显示出弱而中等的生物膜形成。使用市售的锌和二氧化钛纳米粒子对两种产生生物膜的强和弱生物抗甲氧西林的金黄色葡萄球菌进行抗菌活性。因此，纳米颗粒对分离物表现出相当好的活性，可以得出结论，在未来几年中，纳米颗粒可以作为有前途的抗菌剂

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