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首页> 外文期刊>Applied Nanoscience >Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi
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Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi

机译：甘蓝（Broccoli）合成的金纳米颗粒作为抗人类病原菌和真菌的抗菌剂

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Production of antimicrobial agents through the synthesis of gold nanoparticles using green technology has been extensively made consistent by various researchers; yet, this study uses the flower bud’s aqueous extracts of Brassica oleracea (Broccoli) as a reducing agent for chloroauric acid (1?mM). After 30?min of incubation, synthesis of gold nanoparticles (AuNps) was observed by a change in extract color from pale yellow to purple color. Synthesis of AuNps was confirmed in UV–visible spectroscopy at the range of approximately 560?nm. The SEM analysis showed the average nanoparticles size of 12–22?nm. The antimicrobial activity of AuNps was analyzed by subjecting it to human pathogenic bacteria (Gram-positive Staphylococcus aureus and Gram-negative Klebsiella pneumonia ) and fungi ( Aspergillus flavus, Aspergillus niger and Candida albicans ) using disc diffusion method. The broccoli-synthesized AuNps showed the efficient antibacterial and antifungal activity of above-mentioned microbes. It was confirmed that AuNps have the best antimicrobial agent compared to the standard antibiotics (Gentamicin and Fluconazole). When the concentrations of AuNps were increased (10, 25, and 50?μg/ml), the sensitivity zone also increased for all the tested microbes. The synthesized AuNps are capable of rendering high antimicrobial efficacy and, hence, have a great potential in the preparation of drugs used against major bacterial and fungal diseases in humans.
机译：通过使用绿色技术合成金纳米颗粒来生产抗菌剂已被许多研究人员广泛地证明是一致的。但是，这项研究使用的是花蕾的芸苔（Broccoli）水提取物作为氯金酸（1？mM）的还原剂。孵育30分钟后，通过提取物颜色从浅黄色变为紫色观察到了金纳米颗粒（AuNps）的合成。 AuNps的合成在紫外可见光谱中得到证实，范围约为560？nm。 SEM分析显示纳米颗粒的平均尺寸为12-22nm。采用圆盘扩散法，对AuNps进行人病原菌（革兰氏阳性金黄色葡萄球菌和革兰氏阴性克雷伯菌肺炎）和真菌（黄曲霉，黑曲霉和白色念珠菌）的抗菌活性分析。花椰菜合成的AuNps表现出上述微生物的有效抗菌和抗真菌活性。已证实与标准抗生素（庆大霉素和氟康唑）相比，AuNps具有最好的抗菌剂。当AuNps的浓度增加（10、25和50μg/ ml）时，所有测试微生物的敏感区也增加了。合成的AuNps具有很高的抗菌功效，因此在制备用于人类主要细菌和真菌疾病的药物方面具有巨大潜力。

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