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首页> 外文期刊>Advancements in Life Sciences >RETRACTED: Association of anti C1q and ds-DNA levels with the pathogenesis of Lupus Nephritis among SLE patients
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RETRACTED: Association of anti C1q and ds-DNA levels with the pathogenesis of Lupus Nephritis among SLE patients

机译：缩回：SLE患者中抗C1q和ds-DNA水平与狼疮性肾炎发病机制的关系

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Background: Lupus nephritis (LN) is the most common and serious complication associated withSLE and it results in significant morbidity and mortality. It is known by several studies thatpatients of LN have higher levels of anti-dsDNA and anti-C1q compared with SLE patientswithout renal involvement. The current study was designed to determine and compare the levelof anti-dsDNA and anti-C1q in patients of SLE with and without lupus nephritis in the Pakistanipopulation. This current study was also aimed at providing proof that anti-C1q levels are more prominentin LNon-LN SLE as compared to anti-dsDNA. This project may help in the determination of results inPakistan and contribute to the further confirmation of the sensitivity of anti-C1q.Method: The patient samples were collected from Sheikh Zayed hospital, Lahore. These patients wereclinically diagnosed by the Rheumatologists as SLE and LN positive on the basis of ACR and SLEDAIscoring criteria. This study was performed and samples were analyzed in the Department of Medical andLaboratory Sciences, Imperial College of Business Study, Lahore on the patient’s serum by ELISAtechnique.Result: About 38% (12) patients with LN were positive for anti-dsDNA and 31% (9) SLE patients withoutLN were positive whereas about 38.7% (12) were anti-dsDNA negative in LN cases and 58.6% (17) in SLEwithout LN. In case of anti-C1q 100% (31) of these LN patients were positive and 93.1% (27) patients SLEwithout LN showed positive anti C1q results. Only 6.9% (2) patients showed negative results for anti-C1qin LN negative patientsConclusion: The higher levels of anti-C1q suggest that it may be a better diagnostic marker for LN thanthat of anti-dsDNA and that it can be helpful in the prognosis of SLE patients.
机译：背景：狼疮性肾炎（LN）是与SLE相关的最常见和最严重的并发症，它导致明显的发病率和死亡率。几项研究表明，与没有肾脏受累的SLE患者相比，LN患者具有更高的抗dsDNA和C1q水平。本研究旨在确定和比较巴基斯坦人群中患有和不患有狼疮性肾炎的SLE患者的抗dsDNA和抗C1q水平。这项当前的研究还旨在证明LN /非LN SLE中的抗C1q水平与抗dsDNA相比更为突出。该项目可能有助于确定巴基斯坦的结果，并有助于进一步确认抗C1q的敏感性。方法：患者样品来自拉合尔谢赫扎耶德医院。根据ACR和SLEDAI评分标准，风湿病科医师将这些患者临床诊断为SLE和LN阳性。这项研究的进行并通过ELISA技术在拉合尔帝国理工学院医学和实验室科学系对患者的血清进行了分析。结果：约38％（12）的LN患者抗dsDNA阳性，而31％ （9）没有LN的SLE患者为阳性，而在LN患者中约38.7％（12）为抗dsDNA阴性，在没有LN的SLE中为58.6％（17）。在抗C1q的情况下，这些LN患者中有100％（31）为阳性，而没有LN的SLE患者中有93.1％（27）的抗C1q结果为阳性。只有6.9％（2）的患者对抗C1qin LN阴性的患者显示阴性结果结论：较高的抗C1q水平表明它可能是抗LN的诊断标志物，比抗dsDNA的诊断标志物更好，并且有助于预后SLE患者。

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