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首页> 外文期刊>Advancements in Life Sciences >Assessments of kidney function and morphology of tramadol-diclofenac treated albino rats
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Assessments of kidney function and morphology of tramadol-diclofenac treated albino rats

机译：曲马多-双氯芬酸治疗的白化病大鼠的肾脏功能和形态评估

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Background: Tramadol-diclofenac (TD-DF) could be used in chronic pain management.Concurrent use may present renal complications due to their individual nephrotoxic profile. Thepresent study assessed the kidney function and histology of tramadol-diclofenac treated albinorats.Methods: Forty two adult albino rats divided into seven groups A-G were used for this study. Rats wereorally administered with TD (12 mg/kg/day), DF (6 mg/kg/day), and TD-DF for 14 days including tworecovery groups. Rats were weighed and sacrificed at the termination of drug treatment. Serum wasextracted from blood and evaluated for creatinine (Cr), urea (U), uric acid (UA), total protein (TP),albumin (Ab) and serum electrolytes (K+, Na+, Cl-, and HCO3-). Kidneys were excised weighed andevaluated for alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase(AST), superoxide dismutase (SOD), catalase (CAT) glutathione (GSH), glutathione peroxidase (GPX),malondialdehyde (MDA) levels and histological damage.Results: The body weight, absolute and relative kidney weights and serum electrolytes were notsignificantly (p> 0.05) altered in the TD-DF treated rats in comparison to control. However, the levels ofCr, U, UA, AST, ALT, ALP and MDA were significantly (p<0.05) increased whereas Ab, TP, SOD, GSH,GPX and CAT were significantly (p<0.05) decreased in the TD-DF treated rats in comparison totreatments with individual doses of TD and DF. Varying degrees of histological damage were observed inthe kidneys of TD-DF treated rats. However, nephrotoxic effects due to treatment with TD-DF werereversed in the recovery groups.Conclusion: The use of tramadol-diclofenac could be associated with reversible nephrotoxicity; thereforerenal function assessment is advised before tramadol-diclofenac use.
机译：背景：曲马多-双氯芬酸（TD-DF）可用于慢性疼痛治疗，由于其个别的肾毒性特征，同时使用可能会出现肾脏并发症。本研究评估了曲马多-双氯芬酸治疗的白变种的肾脏功能和组织学。方法：42只成年白化病成年大鼠分为七个A-G组。给大鼠口服TD（12 mg / kg /天），DF（6 mg / kg /天）和TD-DF，共14天，包括两个恢复组。在药物治疗终止时，将大鼠称重并处死。从血液中提取血清并评估肌酐（Cr），尿素（U），尿酸（UA），总蛋白（TP），白蛋白（Ab）和血清电解质（K +，Na +，Cl-和HCO3-）。切除肾脏称重并评估丙氨酸转氨酶（ALT），碱性磷酸酶（ALP），天冬氨酸转氨酶（AST），超氧化物歧化酶（SOD），过氧化氢酶（CAT）谷胱甘肽（GSH），谷胱甘肽过氧化物酶（GPX），丙二醛（MDA）含量结果：与对照组相比，经TD-DF处理的大鼠的体重，绝对和相对肾脏重量以及血清电解质无明显变化（p> 0.05）。然而，TD-DF中Cr，U，UA，AST，ALT，ALP和MDA水平显着升高（p <0.05），而Ab，TP，SOD，GSH，GPX和CAT水平显着降低（p <0.05）。与单独剂量的TD和DF的治疗相比在TD-DF治疗的大鼠的肾脏中观察到不同程度的组织学损伤。然而，在恢复组中，由于TD-DF治疗而产生的肾毒性作用被逆转。结论：曲马多-双氯芬酸的使用可能与可逆性肾毒性有关;因此建议在使用曲马多-双氯芬酸之前进行肾功能评估。

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