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首页> 外文期刊>Archives of Biological Sciences >MICROCYSTIN CONGENERS CONTRIBUTE TO TOXICITY IN THE HALOPHILIC CYANOBACTERIUM APHANOTHECE HALOPHYTICA
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MICROCYSTIN CONGENERS CONTRIBUTE TO TOXICITY IN THE HALOPHILIC CYANOBACTERIUM APHANOTHECE HALOPHYTICA

机译:微囊藻毒素同源物对嗜盐蓝细菌环戊类植物的毒性作用

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Aphanothece halophytica is an extremely saline cyanobacterium. This study investigates the toxic nature of the organism and presents the first report of hepatotoxic cyclic heptapeptide microcystin analogs. The activity of the crude extract was investigated in mice. Results showed acute toxicity with mice death at about 4 h. Histopathological examination indicated massive alveolar hemorrhage and extensive congestion in liver cells. Increases in the levels of serum enzymes, i.e., AST (aspartate aminotransferase), ALT (alanine aminotransferase) and LDH (lactate dehydrogenase), provide further evidence of cell injury. An ELISA-based immunological detection kit confirmed the presence of microcystin analogs.
机译:盐生假单胞菌是一种盐度极高的蓝细菌。这项研究调查了该生物体的毒性,并提出了肝毒性环状七肽微囊藻毒素类似物的首次报道。在小鼠中研究了粗提取物的活性。结果显示急性毒性,约4 h导致小鼠死亡。组织病理学检查显示大量肺泡出血和肝细胞广泛充血。血清酶,即AST(天冬氨酸转氨酶),ALT(丙氨酸转氨酶)和LDH(乳酸脱氢酶)水平的升高,提供了细胞损伤的进一步证据。基于ELISA的免疫学检测试剂盒证实了微囊藻毒素类似物的存在。

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