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首页> 外文期刊>Archives of Biological Sciences >FREQUENCY OF ABERRANT PROMOTER METHYLATION OF P15 INK4B AND O 6 -METHYLGUANINE-DNA METHYLTRANSFERASE GENES IN B-CELL NON-HODGKIN LYMPHOMA: A PILOT STUDY
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FREQUENCY OF ABERRANT PROMOTER METHYLATION OF P15 INK4B AND O 6 -METHYLGUANINE-DNA METHYLTRANSFERASE GENES IN B-CELL NON-HODGKIN LYMPHOMA: A PILOT STUDY

机译：B细胞非霍奇金淋巴瘤中P15 INK4B和O 6-甲基鸟嘌呤-DNA甲基转移酶基因异常启动子甲基化的频率：初步研究

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摘要

The methylation status of the target promoter sequences of p15 INK4B (p15) and O 6 -methylguanine-DNAmethyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared tothe hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hyper-methylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. Alllymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV- V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribingthe p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novelfinding and presents both genes as candidates for future studies of the hypermethylation profiles of B-NHL.
机译：通过甲基化特异性PCR研究了10例成年B细胞非霍奇金淋巴瘤（B-NHL）成年患者中p15 INK4B（p15）和O 6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）基因的靶启动子序列的甲基化状态）。与MGMT基因的高甲基化（30％）相比，p15基因的异常高甲基化更为频繁（50％），并且在这两种基因的不同类型的B-NHL中均检测到。 MGMT基因的超甲基化仅与p15基因的超甲基化有关。具有p15和/或MGMT基因高甲基化的淋巴瘤患者具有较高的疾病临床分期（IV-V）。我们显示贫血和/或血小板减少症与p15基因的高度甲基化相关，将p15基因作为B-NHL的潜在预后标志物。 MGMT与p15基因的共甲基化代表了一个新颖的发现，并将这两个基因作为B-NHL高甲基化谱图未来研究的候选基因。

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