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首页> 外文期刊>Archives of clinical infectious diseases. >Prevalence of CTX-M, TEM and SHV Beta-lactamases in Clinical Isolates of Escherichia Coli and Klebsiella Pneumoniae Isolated From Aleppo University Hospitals, Aleppo, Syria
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Prevalence of CTX-M, TEM and SHV Beta-lactamases in Clinical Isolates of Escherichia Coli and Klebsiella Pneumoniae Isolated From Aleppo University Hospitals, Aleppo, Syria

机译：从叙利亚阿勒颇大学医院分离的大肠杆菌和肺炎克雷伯菌的临床分离株中CTX-M，TEM和SHVβ-内酰胺酶的流行

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Background: Extended spectrum β-lactamases (ESBLs) have emerged as a major threat worldwide, with limited treatment options available. Objectives: The present study aimed to estimate the prevalence, possible types of ESBL genes and antibiotic resistant patterns of ESBL-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) . Materials and Methods: A total of 199 clinical isolates of E. coli and K. pneumoniae, collected between October 2010 to March 2012, at three University Hospitals in Aleppo city center, in north Syria, were examined phenotypically and genotypically for ESBL production. Results: The ESBLs were found in (62.89%) of E. coli and (67.5%) of K. pneumoniae isolates. The majority of the typeable isolates harbored two or more ESBL genes (73%). Overall, bla CTX-M-1 was the commonest genotype (81.74%). Resistances of ESBL isolates to other antibiotics were measured: tremithoprim/sulfamethoxazole (72%), nalidixic acid (72%), tetracycline (66%), gentamicin (54%) and ciprofloxacin (53%). Conclusions: Our study showed high ESBL incidence, with CTX-M genotype as the emerging strain in our hospitals. High co-resistance to other non-β-lactam antibiotics is a major challenge for the management of ESBL infections.
机译：背景：广谱β-内酰胺酶（ESBLs）已成为世界范围内的主要威胁，治疗选择有限。目的：本研究旨在评估产生ESBL的大肠杆菌（E. coli）和肺炎克雷伯菌（K. pneumoniae）的ESBL基因的患病率，可能的类型以及抗生素耐药性模式。材料和方法：在2010年10月至2012年3月之间，从叙利亚北部阿勒颇市中心的三所大学医院收集了199株大肠杆菌和肺炎克雷伯菌的临床分离株，对它们的表型和基因型进行了检查，以确定ESBL的产生。结果：ESBLs在大肠杆菌中检出（62.89％），在肺炎克雷伯菌中检出（67.5％）。大多数可分型的分离株都带有两个或多个ESBL基因（73％）。总体而言，bla CTX-M-1是最常见的基因型（81.74％）。测量了ESBL分离物对其他抗生素的抗药性：treemithoprim /磺胺甲恶唑（72％），萘啶酸（72％），四环素（66％），庆大霉素（54％）和环丙沙星（53％）。结论：我们的研究显示，ESBL的发病率很高，CTX-M基因型是我们医院中新兴的菌株。对其他非β-内酰胺类抗生素的高耐药性是ESBL感染管理的主要挑战。

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