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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis
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Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis

机译：Notch信号通路对动脉粥样硬化血管内皮功能障碍与内皮基质转化关系的影响

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Abstract At present, with the improvement of living standards and population aging, the incidence of cardiovascular and cerebrovascular disease is on the rise and has been a serious threat to human health. Statistics show that the current death caused by cardiovascular and cerebrovascular disease has become the first cause of death has been increasing year by year. Therefore, studies on coronary heart disease and atherosclerosis (AS) have become a hot topic in clinical and basic research. In this study, the question of the effect of Notch signalling pathway on the relationship between endothelial dysfunction and endothelial stromal transformation in AS was studied in depth. Based on our results, we drew conclusions as follows. First, the Notch signalling pathway was activated in the atherosclerotic model; secondly, the Notch signalling pathway was demonstrated to enhance AS by promoting vascular endothelial dysfunction; thirdly, it was demonstrated that the Notch signalling pathway was mediated by promoting endothelial and to enhance AS; finally, we confirmed the endothelial function through the Notch signalling pathway to affect the transformation of endothelial stroma to achieve synergistic AS effect. The results of this study have a good guiding significance for the important role of Notch signalling in AS and indicate the ability to influence endothelial function and endothelial stromal transformation by intervening Notch signalling pathway and can affect the relationship between them, and thus eventually achieve the treatment of AS.
机译：摘要当前，随着生活水平的提高和人口老龄化，心脑血管疾病的发病率呈上升趋势，已成为严重威胁人类健康的疾病。统计表明，目前由心脑血管疾病引起的死亡已成为首位死亡原因，并逐年增加。因此，关于冠心病和动脉粥样硬化（AS）的研究已成为临床和基础研究的热门话题。在这项研究中，深入研究了Notch信号通路对AS中内皮功能障碍与内皮基质转化之间关系的影响。根据我们的结果，我们得出以下结论。首先，Notch信号通路在动脉粥样硬化模型中被激活。其次，Notch信号通路被证明通过促进血管内皮功能障碍来增强AS。第三，证明Notch信号通路是通过促进内皮和增强AS介导的。最后，我们通过Notch信号通路证实了内皮功能，影响内皮基质的转化，达到协同增效的作用。这项研究结果对于Notch信号在AS中的重要作用具有良好的指导意义，并表明通过干预Notch信号通路影响内皮功能和内皮基质转化的能力，并可以影响它们之间的关系，从而最终实现治疗AS。

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