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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis
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Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis

机译：缺口信号通路对动脉粥样硬化中血管内皮功能障碍与内皮基质转化关系的影响

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摘要

At present, with the improvement of living standards and population aging, the incidence of cardiovascular and cerebrovascular disease is on the rise and has been a serious threat to human health. Statistics show that the current death caused by cardiovascular and cerebrovascular disease has become the first cause of death has been increasing year by year. Therefore, studies on coronary heart disease and atherosclerosis (AS) have become a hot topic in clinical and basic research. In this study, the question of the effect of Notch signalling pathway on the relationship between endothelial dysfunction and endothelial stromal transformation in AS was studied in depth. Based on our results, we drew conclusions as follows. First, the Notch signalling pathway was activated in the atherosclerotic model; secondly, the Notch signalling pathway was demonstrated to enhance AS by promoting vascular endothelial dysfunction; thirdly, it was demonstrated that the Notch signalling pathway was mediated by promoting endothelial and to enhance AS; finally, we confirmed the endothelial function through the Notch signalling pathway to affect the transformation of endothelial stroma to achieve synergistic AS effect. The results of this study have a good guiding significance for the important role of Notch signalling in AS and indicate the ability to influence endothelial function and endothelial stromal transformation by intervening Notch signalling pathway and can affect the relationship between them, and thus eventually achieve the treatment of AS.
机译：目前，随着生活水平和人口老化的提高，心血管和脑血管病的发生率正在上升，对人类健康有严重威胁。统计数据显示，心血管和脑血管病导致的目前死亡已成为第一个死亡原因一年增加。因此，对冠心病和动脉粥样硬化（AS）的研究已成为临床和基础研究的热门话题。在本研究中，深入研究了Notch信号通路对内皮功能障碍和内皮间基质转化关系的影响。根据我们的结果，我们提出了以下结论。首先，在动脉粥样硬化模型中激活Notch信号通路;其次，陷波信号通路被证明以通过促进血管内皮功能障碍而增强;第三，证明了陷波信号通路是通过促进内皮的介导的，并增强为;最后，我们通过凹口信号通路确认内皮功能，以影响内皮基质的转化，以实现协同作用。该研究的结果对于Notch信号传导中的重要作用具有良好的指导意义，以通过干预Notch信号通路来影响内皮功能和内皮基质转化的能力，并且可以影响它们之间的关系，从而最终实现治疗作为。

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