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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Green approach for synthesis of gold nanoparticles from Nigella arvensis leaf extract and evaluation of their antibacterial, antioxidant, cytotoxicity and catalytic activities
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Green approach for synthesis of gold nanoparticles from Nigella arvensis leaf extract and evaluation of their antibacterial, antioxidant, cytotoxicity and catalytic activities

机译：从黑夜蛾叶提取物中合成金纳米颗粒的绿色方法及其抗菌，抗氧化，细胞毒性和催化活性的评估

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In the present work, we studied the reduction of gold ions into gold nanoparticles using Nigella arvensis leaf extract in the one-step green synthesis method. The formation of N. arvensis gold nanoparticles (NA-GNPs) was confirmed by UV–Vis spectroscopy, XRD, FT-IR and TEM analyses. The XRD pattern confirmed the crystal structure of NA-GNPs, and TEM image showed the small size (3–37?nm) and almost spherical shape of NA-GNPs. NA-GNPs have not shown enhanced antioxidant properties compared to the plant extract while they were active against the clinical isolated bacterial strains. These nanoparticles showed the cytotoxicity effects against H1299 and MCF-7 cancer cell lines with an IC 50 value of 10 and 25?μg/ml, respectively. The extract of N. arvensis contained 212?μg/ml flavonoids and 145?μg/ml phenolic compounds. The contents of total phenolics and flavonoids of biosynthesized NA-GNPs were 68 and 189?μg/ml, respectively. Plant extract and NA-GNPs exhibited a maximum DPPH scavenging activity of 32% and 12%, respectively. The catalytic activity of NA-GNPs against methylene blue was 44%. In conclusion, these results suggest that NA-GNPs can act as a promising candidate for different medical applications produced by cost-effective, eco-friendly and straightforward green method.
机译：在目前的工作中，我们研究了用一步法绿色合成方法使用黑麦草叶提取物将金离子还原成金纳米颗粒。 UV-Vis光谱，XRD，FT-IR和TEM分析证实了猪笼草金纳米颗粒（NA-GNPs）的形成。 X射线衍射图证实了NA-GNP的晶体结构，而TEM图像显示了NA-GNP的小尺寸（3-37nm）和几乎球形。与植物提取物相比，NA-GNPs没有表现出增强的抗氧化特性，但它们对临床分离的细菌菌株具有活性。这些纳米粒子显示出对H1299和MCF-7癌细胞系的细胞毒性作用，IC 50值分别为10和25？μg/ ml。猪笼草的提取物中含有212μg/ ml的类黄酮和145μg/ ml的酚类化合物。生物合成的NA-GNP的总酚和类黄酮的含量分别为68和189？g / ml。植物提取物和NA-GNPs的最大DPPH清除活性分别为32％和12％。 NA-GNP对亚甲基蓝的催化活性为44％。总之，这些结果表明，NA-GNPs可以作为通过经济有效，环保和直接的绿色方法生产的各种医疗应用的有前途的候选者。

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