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首页> 外文期刊>Arab Journal of Urology >Incidental vs symptomatic renal tumours: Survival outcomes
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Incidental vs symptomatic renal tumours: Survival outcomes

机译：偶然性与症状性肾肿瘤：生存结​​果

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Purpose Currently there is an increase in the incidental diagnosis of renal cell carcinoma (RCC). Our aim was to assess the survival of patients with incidental and symptomatic renal tumours who had undergone nephrectomy. Patients and methods We retrospectively assessed 604 patients who underwent renal surgery for RCC between 1983 and 2005. Patients were divided in two groups; group 1 had incidental and group 2 had symptomatic tumours. The median follow-up was 4 and 3.3years for groups 1 and 2, respectively. All patients had surgery in the form of radical or partial nephrectomy. Sex, age, tumour size, type of surgery, pathological characteristics and patient survival in both groups were evaluated. The statistical analysis included the log-rank, Kaplan–Meier and Cox regression tests. Results There were 85 patients (14%) in group 1 (mean age 49.6years) and 519 (86%) in group 2 (mean age 50years). The mean (SEM, range) tumour size was 7.4 (0.4, 1.5–20)cm in group 1 and 9.7 (0.2, 2–38)cm in group 2 ( P <0.001). The most common stage was T1 (52%) and T2 (44%) in groups 1 and 2, respectively, with a predominance of G2 grade and the conventional type histology in both the groups. There was a significant difference in cancer-specific survival (CSS) between the groups (log-rank, P =0.017). The 5- and 10-year CSS was 94% and 94% for group 1, and 82.5% and 79.5% for group 2. Cox regression analysis showed that in group 1, only the tumour mid-zonal location ( P =0.093), tumour stage pT ( P <0.001), grade 1 ( P =0.03), grade 2 ( P =0.01), grade 4 ( P =0.01) and the papillary histological type ( P =0.019) had significant effects on CSS. In group 2, only tumour size ( P =0.022) and stage pN ( P =0.003) had significant effects on CSS. The tumour recurrence rate was 18% and 29% for groups 1 and 2, respectively. Conclusions This large study supports the findings of other smaller studies published previously, confirming that at presentation incidental renal tumours are smaller and their diagnosis provides a better prognosis and longer CSS.
机译：目的目前，肾细胞癌（RCC）的偶然诊断有所增加。我们的目的是评估接受肾切除术的偶发性和有症状肾肿瘤患者的生存率。患者和方法我们回顾性评估了1983年至2005年间接受RCC肾手术的604例患者。第一组患有偶发性肿瘤，第二组患有症状性肿瘤。第1组和第2组的中位随访时间分别为4年和3.3年。所有患者均接受根治性或部分肾切除术。评估两组的性别，年龄，肿瘤大小，手术类型，病理特征和患者生存率。统计分析包括对数秩，Kaplan-Meier和Cox回归检验。结果第1组（平均年龄49.6岁）有85例（14％），第2组（平均年龄50岁）有519例（86％）。第一组的平均肿瘤大小（SEM，范围）为7.4（0.4，1.5–20）cm，第二组的平均肿瘤大小为9.7（0.2，2–38）cm（P <0.001）。第一组和第二组中最常见的阶段分别是T1（52％）和T2（44％），两组均以G2级和常规类型组织学为主。两组之间的癌症特异性生存率（CSS）存在显着差异（对数秩，P = 0.017）。第1组的5年和10年CSS分别为94％和94％，第2组为82.5％和79.5％。Cox回归分析显示，在第1组中，仅肿瘤位于中部区域（P = 0.093），肿瘤分期pT（P <0.001），1级（P = 0.03），2级（P = 0.01），4级（P = 0.01）和乳头组织学类型（P = 0.019）对CSS有显着影响。在第2组中，只有肿瘤大小（P = 0.022）和分期pN（P = 0.003）对CSS有显着影响。第1组和第2组的肿瘤复发率分别为18％和29％。结论这项大型研究支持了先前发表的其他较小研究的结果，证实目前就诊的肾脏肿瘤较小，其诊断可提供更好的预后和更长的CSS。

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