Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation

Muthukumar Amirthalingam; Narayanan Kasinathan; Arul Amuthan; Srinivas Mutalik; M. Sreenivasa Reddy; Udupa Nayanabhirama

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Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation

机译：具有生物活性的PLGA-姜黄素微粒包埋的壳聚糖支架：体内和体外评估

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Abstract Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA–curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (p?Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.

机译：摘要伤口愈合是一个受多个因素影响的复杂过程。在目前的工作中，新型的生物相容性PLGA-姜黄素微粒包埋的壳聚糖支架被制备用于伤口愈合。使用实验设计优化了涉及微粒制备的工艺变量。扫描电子显微镜（SEM）证实了具有嵌入微粒的支架的多孔性质。在第12小时观察到最大释放14％的包封的姜黄素。改良的管稀释法显示支架显着（金黄色葡萄球菌。大鼠切开的伤口中超过50％的伤口在4天内愈合，上皮化期为18天。

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《Artificial cells, nanomedicine, and biotechnology.》 |2017年第2期|共9页
作者
Muthukumar Amirthalingam; Narayanan Kasinathan; Arul Amuthan; Srinivas Mutalik; M. Sreenivasa Reddy; Udupa Nayanabhirama;
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中图分类医用一般科学;
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Chitosan scaffoldcurcumin microparticlesdesign of experimentstissue regenerationwound healing;

机译：壳聚糖支架姜黄素微粒实验设计组织再生伤口愈合;

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1. Bioactive PLGA-curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation [J] . Amirthalingam Muthukumar, Kasinathan Narayanan, Amuthan Arul, Artificial cells, nanomedicine, and biotechnology. . 2017,第1a4期

机译：生物活性PLGA-姜黄素微粒 - 嵌入式壳聚糖脚手架：体外和体内评价
2. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo (vol 79, pg 330, 2010) [J] . Anand Preetha, Nair Hareesh B., Sung Bokyung, Biochemical Pharmacology . 2016,第Null期

机译：姜黄素负载的PLGA纳米颗粒制剂的设计具有增强的细胞吸收能力，更高的体外生物活性和更高的体内生物利用度（第79卷，第330页，2010年）
3. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. [J] . Anand P, Nair HB, Sung Biochemical Pharmacology . 2010,第3期

机译：姜黄素负载的PLGA纳米颗粒制剂的设计具有增强的细胞吸收能力，体外增强的生物活性和体内优异的生物利用度。
4. In vitro and In Vivo Evaluations of Surface Modified Poly(L-lactide-co-glycolide)(PLGA) Scaffold for Ocular Surface Tissue Regeneration [C] . Annual meeting of the Society For Biomaterials . 2002

机译：体外和体内评价表面改性聚（L-丙交酯 - 共乙酰基）（PLGA）支架，用于眼部组织组织再生
5. Development and in vitro/in vivo evaluation of AcHES-PLGA composite microspheres for protein delivery. [D] . Jiang, Ge. 2002

机译：开发用于蛋白质递送的AcHES-PLGA复合微球并进行体外/体内评估。
6. Design of Curcumin Loaded PLGA Nanoparticles Formulation with Enhanced Cellular Uptake and Increased Bioactivity in vitro and Superior Bioavailability in vivo [O] . Preeta Anand, Harish B. Nair, Bokyung Sung, -1

机译：姜黄素加载PLGA纳米粒子配方的设计具有增强的细胞摄取以及体内体外生物活性的增强和卓越的生物利用度
7. RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo [O] . Preetha Anand, Hareesh B. Nair, Bokyung Sung, 2010

机译：缩回：姜黄素加载的PLGA纳米颗粒的设计，具有增强的细胞摄取，并在体外增加生物活性和优异的生物利用度

Bioactive PLGA–curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation

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