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Drug delivery approaches for the treatment of glioblastoma multiforme

机译：治疗多形性胶质母细胞瘤的药物递送方法

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Abstract Context: Glioblastoma multiforme (GBM) is by far the most common and aggressive form of glial tumor. It is characterized by a highly proliferative population of cells that invade surrounding tissue and that frequently recur after surgical resection and chemotherapy. Over the last decades, a number of promising novel pharmacological approaches have been investigated, but most of them have failed clinical trials due to some side-effects such as toxicity and poor drug delivery to the brain. The major obstacle in the treatment of GBM is the presence of the blood–brain barrier (BBB). Due to their relatively high molecular weight, most therapeutic drugs fail to cross the BBB from the blood circulation. Objective: This paper sheds light on the characteristics of GBM and the challenges of current pharmacological treatments. A closer look is given to the role of nanotechnology in the field of drug delivery, and its application in the treatment of brain tumors such as GBM. Method: For this purpose, effort was made to select the most recent studies using predefined search criteria that included at least one of the following keywords in the PubMed and Medline databases: glioblastoma, drug delivery, blood–brain barrier, nanotechnology, and nanoparticle. Conclusion: Breakthrough in nanotechnology offers promising applications in cancer therapy and targeted drug delivery. However, more efforts need to be devoted to the development of novel therapeutic strategies that enable the delivery of drugs to desired areas of the brain with limited side-effects and higher therapeutic efficiency.
机译：摘要背景：胶质母细胞瘤（GBM）是迄今为止最常见和侵袭性的神经胶质瘤。它的特征是高度增殖的细胞侵入周围组织，并且在手术切除和化学疗法后经常复发。在过去的几十年中，已经研究了许多有前途的新颖药理学方法，但是由于诸如毒副作用和药物向大脑的不良传递等副作用，大多数方法都未能通过临床试验。 GBM治疗的主要障碍是血脑屏障（BBB）的存在。由于其相对较高的分子量，大多数治疗药物无法通过血液循环穿过血脑屏障。目的：本文阐明了GBM的特征以及当前药理学治疗的挑战。纳米技术在药物输送领域中的作用及其在脑肿瘤（例如GBM）的治疗中的应用将得到更深入的了解。方法：为此，我们努力使用预定义的搜索条件选择最近的研究，其中至少包括PubMed和Medline数据库中的以下关键字之一：胶质母细胞瘤，药物输送，血脑屏障，纳米技术和纳米颗粒。结论：纳米技术的突破为癌症治疗和靶向药物输送提供了有希望的应用。然而，需要投入更多的精力来开发新的治疗策略，以使药物以有限的副作用和更高的治疗效率输送到所需的大脑区域。

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