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首页> 外文期刊>Archivos Latinoamericanos de Produccion Animal >Role of coactivator PGC-1α in energy balance: Importance in the production of beef cattle
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Role of coactivator PGC-1α in energy balance: Importance in the production of beef cattle

机译：共激活剂PGC-1α在能量平衡中的作用：在肉牛生产中的重要性

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The importance of dietary fat in the expression of multiple genes is clear. In the case of beef cattle, lipid in the form of fatty acids (saturated or unsaturated), vitamin A (mainly retinoic acid), or carotenoids (β-carotene, lutein, lycopen and their metabolites), is obtained constantly from dietary sources. This review attempts to summarize advances in the study of some of the transcription factors and their co- regulators, specifically coactivator PGC-1, which has been observed to affect the transcription of genes involved in energy homeostasis. The capacity of dietary lipids or their metabolic products, to influence PGC-1α, is due in part to the presence of an element of answer to PPAR in its genic promoter, which appears to be conserved in different species of mammals including bovines. It might be important to find nutrients or other types of compounds that could act as ligands of the factors of transcription of specific genes that control metabolic processes such as gluconeogenesis and lipolysis in ruminants, especially bovines, so that in the near future they might contribute to improved production performance of this species.
机译：饮食脂肪在多个基因表达中的重要性是显而易见的。就肉牛而言，经常从饮食中获得脂肪酸（饱和或不饱和），维生素A（主要是视黄酸）或类胡萝卜素（β-胡萝卜素，叶黄素，lycopen及其代谢物）形式的脂质。这篇综述试图总结一些转录因子及其共调节因子，特别是共激活因子PGC-1的研究进展，人们已经观察到它们会影响能量稳态的基因转录。饮食脂质或其代谢产物影响PGC-1α的能力部分归因于其基因启动子中存在PPAR应答元素，而PPAR似乎在包括牛在内的不同哺乳动物物种中都得到了保护。寻找营养物质或其他类型的化合物来充当特定基因转录因子的配体，这些基因可以控制反刍动物（尤其是牛）的糖异生和脂解等代谢过程，这可能很重要，以便在不久的将来它们可能有助于改善了该物种的生产性能。

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