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首页> 外文期刊>Asian journal of animal and veterinary advances >Changes in Plasma Fatty Acid Composition in Hyperlipidemia Dogs
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Changes in Plasma Fatty Acid Composition in Hyperlipidemia Dogs

机译：高脂血症犬血浆脂肪酸组成的变化

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Hyperlipidemia refers to increase of triglyceride (TG) and/or total cholesterol (T-cho) in blood. Fatty Acids (FAs) have important roles in the lipid metabolism. The aim of this study was to determine the FA composition of plasma lipid fractions in dogs with hyperlipidemia and to evaluate the FA composition as a new diagnostic marker for obesity at early stage. Thirty-nine dogs were classified into healthy or hyperlipidemia based on the criteria to diagnose hyperlipidemia. The blood biochemical values, such as TG, T-cho, glucose, insulin, adiponectin and Non-Esterified Fatty Acid (NEFA) were measured. FA composition profile was performed on GC/MS system. The values of plasma TG, insulin and NEFA of the hyperlipidemia group were significantly higher than that of control group. Hyperlipidemia group tended to show lower concentration of adiponectin. It was found that only the levels of TG and NEFA, but not T-cho increased significantly in early stage of hyperlipidemia. In hyperlipidemia group, percentages of myristic acid (C14:0), parmitoleic acid (C16:1) and oleic acid (C18:1) increased in total FAs. And the percentage of C18:1 increased in NEFA. Indeed, the higher level of insulin and lower adiponectin concentration were seen in hyperlipidemia group. These results suggest that appearance of insulin resistance may be the result of increases of certain FAs in early stage of insulin resistance .
机译：高脂血症是指血液中甘油三酸酯（TG）和/或总胆固醇（T-cho）升高。脂肪酸（FAs）在脂质代谢中具有重要作用。这项研究的目的是确定高脂血症犬的血浆脂质组分的FA组成，并评估FA组成作为早期肥胖症的新诊断标记。根据诊断高脂血症的标准，将39只狗分为健康或高脂血症。测量血液的生化值，例如TG，T-cho，葡萄糖，胰岛素，脂联素和非酯化脂肪酸（NEFA）。 FA成分分析在GC / MS系统上进行。高脂血症组的血浆TG，胰岛素和NEFA值明显高于对照组。高脂血症组倾向于显示较低的脂联素浓度。发现在高脂血症的早期，仅TG和NEFA的水平显着增加，而T-cho没有显着增加。在高脂血症组中，总FA中肉豆蔻酸（C14：0），小mit酸（C16：1）和油酸（C18：1）的百分比增加。 NEFA中C18：1的百分比增加。确实，在高脂血症组中，胰岛素水平较高，脂联素浓度较低。这些结果表明，胰岛素抵抗的出现可能是胰岛素抵抗早期某些FAs增加的结果。

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