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首页> 外文期刊>Asian journal of animal and veterinary advances >Lipotoxicity Observed at the Early Phase of Obesity in Cats Fed on High-fat Diet
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Lipotoxicity Observed at the Early Phase of Obesity in Cats Fed on High-fat Diet

机译：在高脂饮食喂养的猫的肥胖早期观察到脂毒性

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The prevalence of obese cats has increased because of over calorie diet and physical inactivity. Obesity has been found to be associated with oxidative stress and Reactive Oxygen Species (ROS). Unfortunately oxidative stress status at the early phase of obesity in high fat fed cats is not well understood. The objectives of this study were (1) To evaluate lipid and glucose metabolism using enzymatic, hormonal and oxidative stress biomarkers at the early obese phase of cats fed on a high-fat diet and (2) To identify rapidly changing variables to use as a diagnostic marker for lipid metabolic disorders in cats. Total 13 domestic female cats were divided into two groups which were fed on control and high-fat diet for eight weeks, respectively. After the feeding period, they were compared in metabolic variables and oxidative stress markers in plasma and tissues. As results, High-fat diet including much long chain fatty acid s promoted rapid changes in lipid metabolism, particularly accelerated β-oxidation of fatty acid s and oxidative stress in the liver of the cats. G6PD, GPx and SOD were increased in the liver. Insulin resistance was not apparent at the early phase of obesity in cats. Plasma activities of SOD also increased at the early phase of obesity in cats. Remarkable alternation for oxidative stress in liver was observed at the early phase of obesity in cats fed on high fat diet and SOD may be a potential marker of the early phase of obesity in cats.
机译：肥胖猫的患病率因饮食热量过多和缺乏运动而有所增加。已发现肥胖与氧化应激和活性氧（ROS）有关。不幸的是，对于高脂喂养的猫，肥胖早期的氧化应激状态还没有被很好地理解。这项研究的目的是（1）在高脂饮食的猫的肥胖早期，使用酶促，激素和氧化应激生物标记物评估脂质和葡萄糖的代谢，以及（2）确定快速变化的变量以用作高脂饮食。猫脂质代谢异常的诊断标记。将总共​​13只家猫雌性分为两组，分别以对照和高脂饮食喂养八周。喂食期后，将它们在血浆和组织中的代谢变量和氧化应激标志物进行比较。结果，包括许多长链脂肪酸的高脂饮食促进了脂质代谢的快速变化，特别是加速了猫的肝脏的脂肪酸的β-氧化和氧化应激。肝脏中G6PD，GPx和SOD升高。在肥胖的早期阶段，猫的胰岛素抵抗并不明显。在肥胖的早期阶段，猫的SOD血浆活性也增加。在以高脂饮食喂养的猫的肥胖早期，观察到肝脏氧化应激的显着改变，SOD可能是猫肥胖早期的潜在标志。

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