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首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >Nanoparticles Based on Hydrophobic Alginate Derivative as Nutraceutical Delivery Vehicle: Vitamin Dsub3/sub Loading
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Nanoparticles Based on Hydrophobic Alginate Derivative as Nutraceutical Delivery Vehicle: Vitamin Dsub3/sub Loading

机译：以疏水藻酸盐衍生物为营养载体的纳米粒子：维生素D 3

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摘要

We report the application of Vitamin D3 (VD3) in nanoparticles of oleoyl alginate ester (OAE)(OAE-VD3). The internalization of fluorescent OAE-VD3 by Caco-2 cells was visualized by confocal laser scanning microscopy. In vivo pharmacokinetic studies showed that incorporation into OAE nanoparticles resulted in increased absorption of VD3. Its application in the treatment of rickets was assayed using a model of nutritionally induced vitamin D-deficiency rickets. The results showed that the encapsulated VD3 had better efficacy than that of the free drug in vivo. Our studies provide evidence that OAE nanoparticles are valuable as nutraceutical delivery vehicles to enhance the absorption of VD(3).
机译：我们报告了维生素D3（VD3）在油酸藻酸酯（OAE）（OAE-VD3）纳米粒子中的应用。通过共聚焦激光扫描显微镜观察Caco-2细胞对荧光OAE-VD3的内在化。体内药代动力学研究表明，掺入OAE纳米颗粒会导致VD3吸收增加。使用营养诱发的维生素D缺乏性病模型分析了其在病中的应用。结果表明，包裹的VD3在体内的疗效优于游离药物。我们的研究提供了证据，证明OAE纳米颗粒可作为提高VD（3）吸收的保健食品输送工具。

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